Results 81 to 90 of about 1,974 (265)

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Nucleate Pool Boiling Heat Transfer Characteristics of Refrigerant/Oil Mixture with Carbon Nanotubes

Zhileng xuebao, 2011
Influence of carbon nanotubes (CNTs) on nucleate pool boiling heat transfer characteristics of refrigerant-oil mixture was investigated experimentally. Four types of CNTs with the outside diameters from 15 nm to 80 nm and the lengths from 1.5 μm to 10 μm
Zhuang Dawei, Peng Hao, Hu Haitao, Ding Guoliang, Zhu Yu   +4 more
doaj  

Droplet desorption modes at high heat flux

EPJ Web of Conferences, 2019
Nonisothermal droplet desorption of aqueous salt solution H2O/LiBr during nucleate boiling was studied experimentally. A droplet was placed on a horizontal heated wall. The initial concentration of salt C0 = 25 %.
Misyura Sergey, Meleshkin Anton
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Comparative analysis of boiling heat transfer on surfaces modified with thermal and mechanical techniques

Production Engineering Archives
Microstructural coatings enable large heat fluxes to be exchanged during nucleate boiling at small temperature differences. Such heat exchangers are highly efficient and can be used in various mechanical systems.
Orman Łukasz J., Radek Norbert, Honus Stanislav, Pietraszek Jacek   +3 more
doaj   +1 more source

Elucidating the effects of surface wettability on boiling heat transfer using hydrophilic and hydrophobic surfaces with laser-etched microchannels

Case Studies in Thermal Engineering
This study explores the nuanced interplay between surface wettability and morphology in nucleate boiling heat transfer. Surfaces with identical microstructures but varying wettability are created on copper substrates using laser texturing and a ...
Domen Žalec, Matic Može, Matevž Zupančič, Iztok Golobič   +3 more
doaj   +1 more source

Distribution of Impurities Concentration in Nucleate Boiling [PDF]

مجله علوم و فنون هسته‌ای, 2008
The development of the mathematical model of mass transfer and diffusion process can determine the behavior of dissolved impurities in the flow boiling within viscous sublayer.
G.R Jahanfarnia
doaj