Results 121 to 130 of about 622 (258)

Advances in micro and nanoengineered surfaces for enhancing boiling and condensation heat transfer: a review. [PDF]

open access: yesNanoscale Adv, 2023
Upot NV   +5 more
europepmc   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

open access: yesThe FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto   +8 more
wiley   +1 more source

Intrinsic specificity of a ‘core’ TIP60 acetyltransferase complex in Drosophila

open access: yesThe FEBS Journal, EarlyView.
The intrinsic substrate selectivity of the Drosophila TIP60‐core acetyltransferase was determined using synthetic nucleosome arrays. Targeted mass spectrometry revealed site‐specific acetylation of histones H2A, H2A.V, and H4, uncovering distinct acetylation rates and patterns across individual lysines.
Silke Krause   +5 more
wiley   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

open access: yesThe FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio   +12 more
wiley   +1 more source

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