Results 111 to 120 of about 2,228,594 (330)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

eLife
While the ratio of nuclei to cell volume is well regulated, it remains largely unexplored in multinucleate organisms. The koji-fungus Aspergillus oryzae, traditionally used in Japanese brewing and fermentation for over a thousand years, is now widely ...
Ayaka Itani, Haruto Motomura, Ken Oda, Hideyuki Yamashita, Kanae Sakai, Ken-ichi Kusumoto, Shinsuke Shigeto, Takehiko Ichikawa, Hosain Mohammad Mubarak, Takeshi Fukuma, Takuya Katayama, Jun-ichi Maruyama, Shunsuke Masuo, Naoki Takaya, Norio Takeshita   +14 more
doaj   +1 more source

Rapid BAL Variability: Re-Emerging Absorption

Frontiers in Astronomy and Space Sciences, 2017
We study BAL variations of SDSS J141955.28+522741.4 utilizing 32 epochs of spectroscopic observations from SDSS. We identify three individual BAL troughs for C iv and one BAL trough for Si iv.
Damla Erakuman, Nurten Filiz Ak, Nurten Filiz Ak   +2 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Prostate cancer detection: Fusion of cytological and textural features

Journal of Pathology Informatics, 2011
A computer-assisted system for histological prostate cancer diagnosis can assist pathologists in two stages: (i) to locate cancer regions in a large digitized tissue biopsy, and (ii) to assign Gleason grades to the regions detected in stage 1.
Kien Nguyen, Anil K Jain, Bikash Sabata
doaj   +1 more source

Alpha and cluster decays of superheavy elements and 2p radioactivity of medium nuclei

, 2022
G. Royer, Q. Ferrier, M. Pineau
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

L-FABP directly interacts with PPARα in cultured primary hepatocytes

Journal of Lipid Research, 2009
Although studies with liver type fatty acid binding protein (L-FABP) gene ablated mice demonstrate a physiological role for L-FABP in hepatic fatty acid metabolism, little is known about the mechanisms whereby L-FABP elicits these effects.
Heather A. Hostetler, Avery L. McIntosh, Barbara P. Atshaves, Stephen M. Storey, H. Ross Payne, Ann B. Kier, Friedhelm Schroeder   +6 more
doaj   +1 more source

Effective Field Theory for Finite Systems with Spontaneously Broken Symmetry

, 2014
We extend effective field theory to the case of spontaneous symmetry breaking in genuinely finite quantum systems such as small superfluid systems, molecules or atomic nuclei, and focus on deformed nuclei.
Papenbrock, T., Weidenmueller, H. A.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source