Results 241 to 250 of about 2,228,594 (330)
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill +8 morewiley +1 more sourcePredicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang +11 morewiley +1 more sourceA self-supervised machine learning pipeline for extracting information from live cell images at multiple doses and timepoints. [PDF]
Sci RepIsaev DY, Liu WP, Cuevas M, Tang Y, Ang K, Wilson C, Mai Q, Adra J, Cruz A, Nguyen K, Ricasa M, Gupta A, Hamadani M, Sridharan D, Yeghiazarians Y, Ameri K. +15 moreeuropepmc +1 more sourceDevelopmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall +5 morewiley +1 more sourceProbing high-momentum protons and neutrons in neutron-rich nuclei
Nature, 2018 M. Duer, O. Hen, E. Piasetzky, H. Hakobyan, L. Weinstein, M. Braverman, E. Cohen, D. Higinbotham, K. Adhikari, S. Adhikari, M. Amaryan, J. Arrington, A. Ashkenazi, J. Ball, I. Balossino, L. Barion, M. Battaglieri, V. Batourine, A. Beck, I. Bedlinskiy, A. Biselli, S. Boiarinov, W. Briscoe, W. Brooks, S. Bueltmann, D. Bulumulla, V. Burkert, F. Cao, D. Carman, A. Celentano, G. Charles, T. Chetry, G. Ciullo, L. Clark, B. Clary, P. Cole, M. Contalbrigo, O. Cortes, V. Crede, R. Cruz-Torres, A. D’Angelo, N. Dashyan, R. Vita, E. Sanctis, M. Defurne, A. Deur, C. Djalali, G. Dodge, R. Dupré, H. Egiyan, A. Alaoui, Lamiaa El Fassi, P. Eugenio, R. Fersch, A. Filippi, T. Forest, G. Gavalian, Y. Ghandilyan, S. Gilad, G. Gilfoyle, K. Giovanetti, F. Girod, E. Golovatch, R. Gothe, K. A. Griffoen, L. Guo, N. Harrison, M. Hattawy, F. Hauenstein, K. Hafidi, K. Hicks, M. Holtrop, C. Hyde, Y. Ilieva, D. Ireland, B. Ishkhanov, E. Isupov, K. Joo, M. Kabir, D. Keller, G. Khachatryan, M. Khachatryan, M. Khandaker, A. Kim, W. Kim, A. Klein, F. Klein, I. Korover, S. Kuhn, L. Lanza, G. Laskaris, P. Lenisa, K. Livingston, I. Macgregor, C. Marchand, N. Markov, B. McKinnon, S. Beck, T. Mineeva, M. Mirazita, V. Mokeev, R. Montgomery, A. Movsisyan, C. Munoz-Camacho, B. Mustapha, S. Nadeeshani, P. Nadel-Turonski, S. Niccolai, G. Niculescu, M. Osipenko, A. Ostrovidov, M. Paolone, E. Pasyuk, M. Patsyuk, A. Papadopoulou, K. Park, D. Payette, W. Phelps, O. Pogorelko, J. Poudel, J. Price, S. Procureur, Y. Prok, D. Protopopescu, M. Ripani, Alessandro Rizzo, G. Rosner, P. Rossi, F. Sabatié, A. Schmidt, C. Salgado, B. Schmookler, R. Schumacher, E. Segarra, Y. Sharabian, G. Smith, D. Sokhan, N. Sparveris, S. Stepanyan, S. Strauch, M. Taiuti, J. Tan, M. Ungaro, H. Voskanyan, E. Voutier, D. Watts, X. Wei, N. Zachariou, J. Zhang, X. Zheng, Z. Zhao +150 moresemanticscholar +1 more sourceVariably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla +10 morewiley +1 more sourceMeCP2-driven chromatin organization controls nuclear stiffness. [PDF]
Commun BiolRomero H, Amiri A, Pabba MK, Zhang H, Berg V, Arroyo M, Prorok P, Zhadan A, Mahmoud M, Trautwein N, Laube B, Dietz C, Stark RW, Cardoso MC. +13 moreeuropepmc +1 more sourceBrainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction
Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding +8 morewiley +1 more source