Results 71 to 80 of about 1,804,617 (325)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Nuclei, Superheavy Nuclei and Hypermatter in a chiral SU(3)-Modell

, 2001
A model based on chiral SU(3)-symmetry in nonlinear realisation is used for the investigation of nuclei, superheavy nuclei, hypernuclei and multistrange nuclear objects (so called MEMOs).
A. R. Bodmer, B. D. Serot, Ch. Beckmann, D. J. Millner, D. J. Prowse, D. Zschiesche, F. Ineichen, G. C. Bonnazzola, H. de Vries, H. Stöcker, I. Vidaña, J. Blocki, J. Friedrich, J. Mares, J. Schaffner, J. Schaffner, J. Schaffner, K. Rutz, M. Bender, M. Danysz, M. Danysz, M. Gell-Mann, M. Juric, M. May, M. Rufa, M. Rufa, P. Papazoglou, P. Papazoglou, P. Papazoglou, Q. N. Usmani, R. Bertini, R. Bertini, R. Bertini, R. E. Chrien, R. E. Chrien, R. H. Dalitz, S. Ajimuetra, S. Aoki, S. Hofmann, S. Hofmann, S. Hofmann, S. Schramm, S. Ćwiok, T. Cantwell, T. Hasegawa, W. Brückner, W. Brückner, W. Greiner, W. von Oertzen, X. Campi, Y. Oganessian   +50 more
core   +1 more source

Clusters in Light Nuclei [PDF]

Acta physica Polonica. B, 2010
A great deal of research work has been undertaken in the alpha-clustering study since the pioneering discovery, half a century ago, of 12C+12C molecular resonances. Our knowledge of the field of the physics of nuclear molecules has increased considerably and nuclear clustering remains one of the most fruitful domains of nuclear physics, facing some of ...
Beck, C., Papka, P., Zafra, A. Sanchez I, Thummerer, S., Azaiez, F., Bednarczyk, P., Courtin, S., Curien, D., Dorvaux, O., Goasduff, A., Lebhertz, D., Nourreddine, A., Rousseau, Marc, Salsac, M. -D., von Oertzen, W., Gebauer, B., Wheldon, C., Kokalova, Tz., Efimov, G., Zherebchevsky, V., Schulz, Ch., Bohlen, H. G., Kamanin, D., de Angelis, G., Gadea, A., Lenzi, S., Napoli, D. R., Szilner, S., Milin, M., Catford, W. N., Jenkins, D. G., Royer, Guy   +31 more
openaire   +6 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Protein kinase FAM20C—when subcellular localization matters

FEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Synthesis of Superheavy elements and Theory of Atomic Nucleus [PDF]

, 2001
The connection of synthesis of long-lived superheavy nuclei and existence of the island of stability with the choice of realistic nuclear potential is discussed: the behaviour of the average field of nuclei is an important element of nuclear models.
Gareev, F. A., Kalinkin, B. N.
core   +2 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

A morphometric analysis of the nuclei and nucleoli in tumor cells in lymphogranulomatosis, diffuse large B-cell lymphoma and anaplastic large cell lymphoma

Терапевтический архив, 2009
Aim. To make a comparative morphometric analysis of the nuclei and nucleoli of tumor cells in lymphogranulomatosis (LGM), diffuse large B-cell lymphoma (DLBCL) and anaplastic large cell lymphoma (ALCL) for differential diagnosis of these lymphomas ...
Lana Anzorovna Gopgidze, I A Vopob'ev, L A Gorgidze, I A Vorobyev   +3 more
doaj  

Anharmonic vibrations in nuclei [PDF]

Nuclear Physics A, 2003
In this letter, we show that the non-linearitites of large amplitude motions in atomic nuclei induce giant quadrupole and monopole vibrations. As a consequence, the main source of anharmonicity is the coupling with configurations including one of these two giant resonances on top of any state.
Fallot, Muriel, Chomaz, Ph., Andres, M.V., Catara, F., Lanza, E.G., Scarpaci, J.A.   +5 more
openaire   +6 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source