Results 111 to 120 of about 2,571,740 (262)
Signal Transduction and Targeted TherapyNucleic acid aptamers, often referred to as “chemical antibodies,” are versatile, specific, and easily modifiable functional nucleic acids. There is a growing focus on new methods for the selection and target validation of aptamers, with the aim of ...
Ding-Kun Ji +9 more
doaj +1 more source
eLife, 2013 Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which multiple same-strand substitutions at C:G pairs spaced one to several hundred nucleotides apart are clustered over kilobase-sized regions, often associated with ...
Benjamin JM Taylor +8 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
A Review of Peptide Nucleic Acid [PDF]
, 2015 Peptide Nucleic Acid (PNA) is a nucleobase oligomer in which the whole backbone is mainly replaced by N-(2- aminoethyl) glycine units. PNA is considered as DNA with a neutral peptide backbone due to negative charged sugar–phosphate backbone.
Shafiquzzaman Siddiquee +2 more
core +2 more sources
DETECTION OF GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1 (GPD1) MUTATIONS IN EGYPTAIN FEMALES
Bulletin of Pharmaceutical Sciences. Assiut UniversityObjectives: This preliminary study aimed to detect two GPD1 mutations—rs200327418 (c.361-1G>C; p.Ile119fsX94) and rs199673455 (G>A / G>C)—in women with and without history of cancer. Subjects and Methods: Forty-five DNA samples were screened for
Halima Salem +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.A hybrid PEDOT/Fc‐LPEI conducting/redox polymer bioanode synergistically improves microbial extracellular electron transfer (EET) in Shewanella oneidensis MR‐1. The dual‐layer interface delivers 18‐fold higher current output and 27‐fold greater charge collected than bare carbon felt, highlighting an effective strategy for high‐performance ...
Shenghan Gu +4 more
wiley +1 more source
A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing [PDF]
, 2018 STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce type I interferon (IFN) production.
Cheng, Y +26 more
core +1 more source
DNA Tweezers with Replaceable Clamps for the Targeted Degradation of Cell Membrane Proteins
PharmaceuticsBackground: Cell membrane proteins play crucial roles in signal transduction and nutrient transport. Many membrane proteins are reportedly overexpressed in cancer cells, which is closely related to cancer progression.
Yang Sun +7 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Melanin content directly controls fungal spore mechanical properties, with pigmented spores achieving rupture forces two orders of magnitude higher than hyaline spores. Environmental stress drives this quantity‐quality tradeoff; stressed species invest energy in melanin‐reinforced, mechanically superior thick‐walled, super‐hydrophobic spores, while ...
Atul Agrawal, Steven E. Naleway
wiley +1 more source
Design of interacting multi-stable nucleic acids for molecular information processing
, 2011 Despite an exponential increase in computing power over the past decades, present information technology falls far short of expectations in areas such as cognitive systems and micro robotics.
Zauner, Klaus-Peter +5 more
core +1 more source