Results 191 to 200 of about 815,217 (265)

Smartphone-Based Peptide Nucleic Acid (PNA) Probe-Assisted Potentiometric Biosensor for Point-of-Care Testing of SARS-CoV-2 Nucleic Acid. [PDF]

Anal Chem
Ozer T, Jampasa S, Lomae A, Ruecha N, Sagdic O, Vilaivan T, Henry CS, Chailapakul O.   +7 more
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Global stakeholder preferences for point-of-care HIV nucleic acid amplification tests: A conjoint study. [PDF]

PLoS One
Palamountain KM, Achar C, Kirby RP, Manabe YC, Boeras D, Maimaran M.   +5 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Split Activator Assembly via Aptamer Binding Enables CRISPR-Cas12a Activation With Non-Nucleic Acid Targets. [PDF]

Small Methods
Tharu RJ, Imtiaz Y, Singha S, Hanson E, Gold RE, Royzen P, Yigit MV.   +6 more
europepmc   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

DeepPNI: a language- and graph-based model for mutation-driven protein-nucleic acid binding energetics. [PDF]

Nucleic Acids Res
Mondal S, Mondal T, Pramanik S, Mehra R.
europepmc   +1 more source

Finger-actuated microfluidic device for point-of-care circulating cell-free nucleic acid extraction.

Lab Chip
Musaddaq G, Ehsan L, Yoga Y, Castillo J, Marriott L, Leslie NR, Williamson D, Tran T, Lim CK, Kersaudy-Kerhoas M.   +9 more
europepmc   +1 more source

Red-teaming as an imperative for strengthening synthetic nucleic acid screening. [PDF]

Front Bioeng Biotechnol
Khan Y, Thorat K.
europepmc   +1 more source

4MRNA: a new approach for nucleic acid molecular replacement using models with diverse parameter patterns. [PDF]

RNA
Ando S, Kondo J.
europepmc   +1 more source