Results 221 to 230 of about 781,538 (317)

Nucleic Acid-Modified Nanoparticles for Cancer Therapeutic Applications. [PDF]

Small
Qin Y, Chen X, Willner I.
europepmc   +1 more source

Amphiphilic nucleic acid conjugates for transfection of differentiated intestinal cells

, 2016
Elena Moroz
openalex   +2 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

<SUP>13</SUP>C-NMR Relaxation Analysis of Nucleic Acid Structure and Dynamics

, 2000
Chojiro KOJIMA, Masatsune KAINOSHO
openalex   +2 more sources

Antibody‐Functionalized DNA Hydrogels Recognize and Isolate Living Tumor Cells

Advanced Materials Interfaces, EarlyView.
We present a novel strategy using DNA Y‐motif nanostar hydrogels and DNA‐functionalized antibodies for precise live‐cell manipulation. Target cells are labeled with DNA sticky ends that hybridize with DNA Y‐motifs, enabling their incorporation and capture within the hydrogel during self‐assembly.
Laura Bourdon, Audrey Cochard, Yannick Tauran, Yoshinobu Sugitani, Yusuke Sato, Masahiro Takinoue, Hiroyuki Fujita, Teruo Fujii, Soo Hyeon Kim, Anthony J. Genot   +9 more
wiley   +1 more source

Smart Nucleic Acid Hydrogel-Based Biosensors: From Molecular Recognition and Responsive Mechanisms to Applications. [PDF]

Biosensors (Basel)
Xu L, Zhu L, Wang X, Zhang W, He X, Zhang Y, Xu W.   +6 more
europepmc   +1 more source

Enrichment of Hypermethylated DNA on Chip for Cervical Cancer Detection

Advanced Materials Interfaces, EarlyView.
A microfluidic chip coated with surface‐immobilized methyl binding domain 2 (MBD‐2) protein receptors, is able to bind hypermethylated DNA (hmDNA) from a cancer cell line selectively. Quantification by quantitative polymerase chain reaction (qPCR) shows a 30‐fold enrichment in cervical cancer target DNA.
Ruben W. Kolkman, Birgit M. M. Wever, Jeanne Elisabeth van Dongen, Annina P. van Splunter, Johan G. Bomer, Renske D. M. Steenbergen, Loes I. Segerink, Jurriaan Huskens   +7 more
wiley   +1 more source

Protein-nucleic acid language model-assisted design of precise and compact adenine base editor. [PDF]

Nat Commun
Ren J, Yao J, Cao Q, Li Y, Li Y, Zhang Z, Ge X, Wang S, Zhang Y, Wang X, Zhang X.   +10 more
europepmc   +1 more source

A new size‐independent score for pairwise protein structure alignment and its application to structure classification and nucleic‐acid binding prediction

, 2012
Yuedong Yang, Jian Zhan, Huiying Zhao, Yaoqi Zhou   +3 more
openalex   +2 more sources

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source