Results 221 to 230 of about 585,337 (297)

Cytokine mRNA Delivery and Local Immunomodulation in the Placenta Using Lipid Nanoparticles

Advanced Therapeutics, EarlyView.
This article evaluates lipid nanoparticles to deliver immunomodulatory mRNA to placental cells and mouse placentas to study and treat the immune underpinnings of placenta‐related diseases. Lipid nanoparticles induce cytokine secretion and macrophage polarization toward an anti‐inflammatory state.
Samuel I. Hofbauer, Luisa A. Fink, Rachel E. Young, Tara Vijayakumar, Katherine M. Nelson, Nia Bellopede, Mohamad‐Gabriel Alameh, Drew Weissman, Jason P. Gleghorn, Rachel S. Riley   +9 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Enhancing nucleic acid delivery by the integration of artificial intelligence into lipid nanoparticle formulation. [PDF]

Front Med Technol
Amoako K, Mokhammad A, Malik A, Yesudasan S, Wheba A, Olagunju O, Gu SX, Yarovinsky T, Faustino EVS, Nguyen J, Hwa J.   +10 more
europepmc   +1 more source

EFFECTS OF A FOLIC ACID ANTAGONIST ON NUCLEIC ACID METABOLISM

, 1952
David A. Goldthwait, Aaron Bendich
openalex   +1 more source

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

CHEMICAL STUDIES OF BULL SPERMATOZOA. LIPID, SULFUR, CYSTINE, NITROGEN, PHOSPHORUS, AND NUCLEIC ACID CONTENT OF WHOLE SPERMATOZOA AND OF THE PARTS OBTAINED BY PHYSICAL MEANS

, 1941
Charles A. Zittle, Robert A. O'Dell
openalex   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

Future perspectives of GMO detection in agriculture: strategies for electrochemical nucleic acid detection. [PDF]

Mikrochim Acta
Kuprešanin A, Jarić S, Novaković Z, Radović M, Pavlović M, Knežić T, Šašić Zorić L, Janjušević L, Pavlović Z.   +8 more
europepmc   +1 more source

INCORPORATION OF GLYCINE-2-C14 INTO PROTEINS AND NUCLEIC ACIDS OF THE RAT

, 1951
G. A. LePage, Charles Heidelberger
openalex   +1 more source