Results 231 to 240 of about 788,142 (267)

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Controlling intracellular processing to enhance spherical nucleic acid immune stimulation. [PDF]

Proc Natl Acad Sci U S A
Kang J, Teplensky MH, Dittmar JW, Evangelopoulos M, Hwang J, Mirkin CA.   +5 more
europepmc   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Why implementation gaps could undermine synthetic nucleic acid oversight. [PDF]

Front Bioeng Biotechnol
Gillum DR, Moritz RL.
europepmc   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Exploring GNRA tetraloop-like motifs in nucleic acid 3D structures. [PDF]

Sci Rep
Bujnicki JM, Baulin EF.
europepmc   +1 more source

Babesia nucleic acid prevalence among blood donors in southern Québec. [PDF]

Transfusion
Renaud C, Fedorova M, Simard NC, Côté JF, Linnen JM, Baron G, Milord F, Thivierge K, Irace-Cima A, Groves JA, Townsend RL, Saa P, Tonnetti L, Stramer SL, Germain M, Lewin A.   +15 more
europepmc   +1 more source

Nucleic Acid-Modified Nanoparticles for Cancer Therapeutic Applications. [PDF]

Small
Qin Y, Chen X, Willner I.
europepmc   +1 more source

Engineering filamentous potato virus X as a platform nanotechnology for nucleic acid gene delivery. [PDF]

Sci Rep
Duoto B, Tong M, Barkovich KJ, Schuphan J, Mali P, Steinmetz NF.   +5 more
europepmc   +1 more source

Quantitative SERS-Based Sandwich-Hybridization Assay for Nucleic Acid Detection. [PDF]

ACS Omega
Shahsavar K, Mostafa A, Mahdi-Joest D, Zverev AS, Kogikoski S, Hosseini M, Bald I.   +6 more
europepmc   +1 more source