From Code to Life: The AI‐Driven Revolution in Genome Editing
Advanced Science, EarlyView.This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li +10 more
wiley +1 more source
Mechanism of pH-sensitive Amphiphilic Endosomal Escape of Ionizable Lipid Nanoparticles for Cytosolic Nucleic Acid Delivery. [PDF]
Pharm ResLu ZR, Sun D.
europepmc +1 more source
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source
Correction to 'The N = 1 Collaborative: advancing customized nucleic acid therapies through collaboration and data sharing'. [PDF]
Nucleic Acids Reseuropepmc +1 more source
Three- and four-stranded nucleic acid structures and their ligands. [PDF]
RSC Chem BiolHashimoto Y +4 more
europepmc +1 more source
Author Correction: Between hope and reality: treatment of genetic diseases through nucleic acid-based drugs. [PDF]
Commun BiolBaylot V +4 more
europepmc +1 more source
Reconfigurable acoustic streaming tweezers enabled portable liquid handler for nucleic acid extraction. [PDF]
Ultrason SonochemLi T +6 more
europepmc +1 more source
Involvement of nucleic acid-sensing toll-like receptors in human diseases and their controlling mechanisms. [PDF]
J Biomed SciLin YS +4 more
europepmc +1 more source