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Nucleic acids delivering nucleic acids
Advanced Drug Delivery Reviews, 2018Nucleic acid therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent innovative and highly promising molecules for the safe treatment of a wide range of pathologies. The efficiency of systemic treatments is impeded by 1) the need to overcome physical and functional barriers in the organism, and 2) to accumulate in the intracellular ...
Catuogno S +3 more
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Annual Review of Biochemistry, 1957
Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Journal of the American Chemical Society, 2012
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
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A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
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Acta Crystallographica Section D Biological Crystallography, 2002
The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
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Current Opinion in Biotechnology, 2005
Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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