Results 221 to 230 of about 183,908 (336)

MP11-04 MENINGOCOCCAL URETHRITIS. A PITFALL IN THE CONVENTIONAL DIAGNOSTIC PROCESS BASED ON THE NUCLEIC ACID AMPLIFICATION TEST IN MEN WITH SUSPECTED GONOCOCCAL URETHRITIS [PDF]

, 2017
Munekado Kojima, Yasufumi Yada, Kazuhiko Yosihida, Yosimasa Hayase   +3 more
openalex   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Multicenter Comparison of Nucleic Acid Amplification Tests for the Diagnosis of Rectal and Oropharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae Infections. [PDF]

J Clin Microbiol, 2022
Van Der Pol B, Chernesky M, Gaydos CA, Hook EW, Joseph AM, Christensen K, Arcenas R, Boutwell A, Wiesenfeld HC, Taylor SN, Mayer KH, Golden MR, Moncada J, Jang D, Schachter J, ExGen Study Group Kristal Aaron University of Alabama at Birmingham, Paula Dixon University of Alabama at Birmingham, Karen Eckert Becton, Dickinson and Company, BD Life Sciences – Integrated Diagnostic Solutions, Shiaolan Y. Ho Abbott, Medical Affairs, Michael Lewinski Roche Diagnostic Solutions, Kevin Luk Roche Diagnostic Solutions, Carl McGill Abbott, Medical Affairs, Shiv Parmar Becton, Dickinson and Company, BD Life Sciences – Integrated Diagnostic Solutions, James Price Becton, Dickinson and Company, BD Life Sciences – Integrated Diagnostic Solutions, Charles Rivers University of Alabama at Birmingham.   +32 more
europepmc   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Low-complexity automated nucleic acid amplification tests for extrapulmonary tuberculosis and rifampicin resistance in adults and adolescents. [PDF]

Cochrane Database Syst Rev
Kohli M, Inbaraj LR, Salomon A, Scandrett K, Korobitsyn A, Ismail N, Srinivasalu VA, Daniel J, Steingart KR, Takwoingi Y.   +9 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Chemotherapy and anti-CD20 monoclonal antibody impact on SARS-CoV-2 nucleic acid amplification tests in hematologic malignancies: a retrospective study. [PDF]

BMC Infect Dis
Kinoshita K, Maruyama W, Miyake H, Sada RM.   +3 more
europepmc   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Diagnostic accuracy of low-complexity, manual nucleic acid amplification tests for the detection of pulmonary and extrapulmonary tuberculosis in adults and adolescents: a systematic review and meta-analysis∗. [PDF]

Lancet Microbe
Inbaraj LR, Srinivasalu VA, Sathya Narayanan MK, Bhaskar A, Daniel J, Scandrett K, Korobitsyn A, Ismail N, Takwoingi Y.   +8 more
europepmc   +1 more source

Exploring beyond the limit: How comparative stochastic performance affects retesting outcomes in six commercial SARS CoV-2 nucleic acid amplification tests. [PDF]

J Clin Virol Plus, 2022
Chan HT, Keung MHT, Nguyen I, Ip ELO, Chew SM, Siler D, Saville M, Hawkes D.   +7 more
europepmc   +1 more source