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Polynucleotide analogues as possible primitive precursors of nucleic acids

Origins of life and evolution of the biosphere, 1986
Activated derivatives of purine-containing deoxynucleosidedimonophosphates spontaneously oligomerize to produce pyrophosphatelinked oligonucleotide analogues. These analogues are of potential interest as models of primitive, polynucleotide precursors.
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Carboranyl Precursors of Nucleic Acids--Potential DNA Probes for BNCT

1992
It has been determined that the biological effectiveness of BNCT will be maximized if the capture reaction were to occur in the cell nucleus in comparison with the cytoplasm, on cell membrane or in extracellular spaces.1–2 This has been the basis for the ongoing synthesis of boron compounds which are chemically similar to the building blocks of the ...
A. H. Soloway   +5 more
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Uptake of nucleic acid, protein and carbohydrate precursors by hen-oviduct lipids

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
Abstract 1. 1. The incorporation of radioactive materials suspected of being present in various amino acid-containing lipid fractions was tested. After simultaneous double isotope incubations, the lipids were fractionated in different chromatographic systems and assayed for the incorporation of each type of radioactive label.
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Altered incorporation of nucleic acid precursors by mycoplasma-infected mammalian cells in culture.

Experimental Cell Research, 1972
A. Perez   +3 more
semanticscholar   +1 more source

On the use of different nucleic acid precursors for the measurement of microbial nucleic acid turnover

1984
The incorporation of the following nucleic acid precursors into nucleic acids of the microbial community from lake Großer Plöner See was measured, (methyl-3 H)thymidine, (5,6-3 H)uridine, (methyl-3H)thymine, (2-3H)adenine, (5-3H)orotic acid, L-(U-14C)aspartic acid, (U-14C)glycine, D-(l-14C)ribose and 32P phosphate.
Witzel, K., Graf, G.
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Nutritional folate-deficiency in Chinese hamster ovary cells. Chromosomal abnormalities associated with perturbations in nucleic acid precursors.

Cancer Genetics and Cytogenetics, 1990
Bisharah Libbus   +3 more
semanticscholar   +1 more source

Radioactive nucleic acids-precursors: their potential value as tumor-localizing agents.

Strahlentherapie, 1977
The distribution of 125I-uracil and 125I-deoxyuridine in tumor-bearing animals has been studied. 125I-deoxyuridine shows the characteristics of a tumor-scanning agent. The metabolic incorporation by tumors of this DNA-precursor indicates a potential value of this radiocompound for their detection, differentiation and follow-up of their evolution after ...
L J, Anghileri, M, Heidbreder, R, Mathes
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