Results 121 to 130 of about 651,023 (306)

Molecular Probe Designs For Nucleic Acid Based Detection [PDF]

, 2013
Nucleosides and nucleotides are powerful building units for creating functional molecules with novel properties. The structural and functional variations of these biomolecules have caused a renaissance of nucleic acid chemistry and biology, and paved the
Kaur, Manindar
core   +2 more sources

Oligonucleotide analogues with cationic backbone linkages

Beilstein Journal of Organic Chemistry, 2018
Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ...
Melissa Meng, Christian Ducho
doaj   +1 more source

Systematic Comparison of Commercial Uranyl‐Alternative Stains for Negative‐ and Positive‐Staining Transmission Electron Microscopy of Organic Specimens

Advanced Healthcare Materials, EarlyView.
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling, Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick   +4 more
wiley   +1 more source

Analysis of the possible helical structures of nucleic acids and polynucleotides. Application of (n-h) plots. [PDF]

, 1976
N. Yathindra, M. Sundaralingam
openalex   +1 more source

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal‐Phenolic Networks

Advanced Healthcare Materials, EarlyView.
Small extracellular vesicles (sEVs) are encapsulated into protective shells composed of metal‐phenolic networks (MPNs) and secondary poly(ethylene glycol) layers. This surface modification approach enhances the storage stability of sEVs while maintaining their integrity and functionality. The shells can be selectively disassembled under mild conditions.
Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J. Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima   +8 more
wiley   +1 more source

Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

Beilstein Journal of Organic Chemistry, 2018
Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base–base FRET, works as a spectroscopic ruler and protractor.
Mattias Bood, Sangamesh Sarangamath, Moa S. Wranne, Morten Grøtli, L. Marcus Wilhelmsson   +4 more
doaj   +1 more source

Antiviral nucleic acid derivatives. III. Crystal structure of 5-ethynyl-2'-deoxyuridine [PDF]

, 1978
P J Barr, T.A. Hamor, Richard Walker
openalex   +1 more source

Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation

Advanced Healthcare Materials, EarlyView.
This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth, Zachary S.C.S. Froom, Natasha D. Osborne, Christian N. Rempe, Brenden Wheeler, Kyle Medd, Neal I. Callaghan, Huikang Qian, Abhinav P. Acharya, Carlie Charron, Locke Davenport Huyer   +10 more
wiley   +1 more source

Nucleic acid structure and sequence probing using fluorescent base analogue tC^o [PDF]

The fluorescent cytosine analog tC(o) is on average the brightest probe of its kind and, moreover, it introduces minimal perturbations to the normal secondary structure of DNA.
Börjesson, Karl, Sandin, Peter, Wilhelmsson, Marcus   +2 more
core  

Photochemical regulatory strategies for nucleic acid function and their biomedical applications

Interdisciplinary Medicine
Nucleic acids are not only essential biomolecules that drive critical life processes such as growth, development, reproduction, inheritance, and mutation, but also serve as significant markers for disease diagnosis, pathogen identification, and cancer ...
Menglu Hu, Yihui Wang, Xiaoming Zhou
doaj   +1 more source