Results 211 to 220 of about 737,876 (305)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Structural analysis of uridine modifications in solved RNA structures. [PDF]

NAR Genom Bioinform
Arteaga SJ, Znosko BM.
europepmc   +1 more source

DNA Origami‐Templated Aptamer Chiral Structures Realize Cellular Enantioselectivity

Advanced Materials, EarlyView.
Aptamers displayed on tubular DNA origami nanostructures in defined chiral orientations (left‐ or right‐handed) exhibit enantioselective interactions with cell surface target proteins. While the right‐handed configuration supports only transient binding, the left handedness energetically favors protein dimerization and promotes subsequent ...
Tingjie Song, Abhisek Dwivedy, Dhanush Gandavadi, Gayatri Chandran, Yiquan An, Mengxi Zheng, Xiaojing Wang, Lifeng Zhou, Yang Zhao, Xing Wang   +9 more
wiley   +1 more source

Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA. [PDF]

Nucleic Acids Res
Cox LB, Mattick JS, Middleton IA, Rizzuto FJ, Thordarson P.   +4 more
europepmc   +1 more source

2P125 Enhancement of a Quadruplex-ribozyme activity in response to K^+: a quadruplex-forming complementary DNA enables accurate switching(05A. Nucleic acid: Structure & Property,Poster)

, 2013
Yudai Yamaoki, Tsukasa Mashima, Takashi Nagata, Masato Katahira   +3 more
openalex   +2 more sources

MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes [PDF]

, 2004
Ian Davis, Louann W. Murray, Jane S. Richardson, David Richardson   +3 more
openalex   +1 more source

Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells

Advanced Materials, EarlyView.
This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur, Aljaž Kavčič, Uroš Jagodič, Rok Podlipec, Matjaž Humar   +4 more
wiley   +1 more source

Functional nucleic acid Hydrogels: Paving the way for Next-generation bone and cartilage regeneration. [PDF]

Mater Today Bio
Tian Y, Li X, Jiang Y, Zeng W, Yu X, Shi S, Lin Y.   +6 more
europepmc   +1 more source

Amino Acid Stabilization of Nucleic Acid Secondary Structure: Kinetic Insights from Single-Molecule Studies

, 2018
D A Nicholson, Abhigyan Sengupta, Hsuan-Lei Sung, David J. Nesbitt   +3 more
openalex   +2 more sources

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source