Results 21 to 30 of about 737,876 (305)
Amyloid-associated nucleic acid hybridisation. [PDF]
PLoS ONE, 2011 Nucleic acids promote amyloid formation in diseases including Alzheimer's and Creutzfeldt-Jakob disease. However, it remains unclear whether the close interactions between amyloid and nucleic acid allow nucleic acid secondary structure to play a role in ...
Sebastian Braun +5 more
doaj +1 more source
Argonaute protein-based nucleic acid detection technology
Frontiers in Microbiology, 2023 It is vital to diagnose pathogens quickly and effectively in the research and treatment of disease. Argonaute (Ago) proteins are recently discovered nucleases with nucleic acid shearing activity that exhibit specific recognition properties beyond CRISPR ...
Zhiyun Wu +3 more
doaj +1 more source
Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA
Cell Reports, 2015 We present the crystal structure of the junction-resolving enzyme GEN1 bound to DNA at 2.5 Å resolution. The structure of the GEN1 protein reveals it to have an elaborated FEN-XPG family fold that is modified for its role in four-way junction resolution.
Yijin Liu +5 more
doaj +1 more source
BioTechniques, 2020 Nucleic acid precipitation is important for virtually all molecular biology investigations. However, despite its crucial role, a systematic study of the influence factors of nucleic acid precipitation has not been reported.
Yalin Li +10 more
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Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source
Comparison of bacterioneuston and bacterioplankton dynamics during a phytoplankton bloom in a fjord mesocosm [PDF]
, 2009 The bacterioneuston is the community of Bacteria present in surface microlayers, the thin surface film that forms the interface between aquatic environments and the atmosphere. In this study we compared bacterial cell abundance and bacterial community
Cunliffe, Michael +5 more
core +2 more sources
F1000Research, 2019 The nucleolytic ribozymes carry out site-specific RNA cleavage reactions by nucleophilic attack of the 2′-oxygen atom on the adjacent phosphorus with an acceleration of a million-fold or greater.
David M.J. Lilley
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Virus-like particles (VLPs) are macromolecular structures with great potential as vehicles for the targeted administration of functional molecules. Loaded with nucleic acids, VLPs are a promising approach for nanocarriers needed for gene therapy.
Angela Valentic +2 more
doaj +1 more source
Optimizing scoring function of protein-nucleic acid interactions with both affinity and specificity. [PDF]
PLoS ONE, 2013 Protein-nucleic acid (protein-DNA and protein-RNA) recognition is fundamental to the regulation of gene expression. Determination of the structures of the protein-nucleic acid recognition and insight into their interactions at molecular level are vital ...
Zhiqiang Yan, Jin Wang
doaj +1 more source
Structural studies of protein–nucleic acid complexes: A brief overview of the selected techniques
Computational and Structural Biotechnology Journal, 2023 Protein–nucleic acid complexes are involved in all vital processes, including replication, transcription, translation, regulation of gene expression and cell metabolism.
Kamil Szpotkowski +2 more
doaj +1 more source