Results 121 to 130 of about 34,814 (245)

System-level measurement, modeling, and manipulation of RNA. [PDF]

RNA
Zavolan M, Yeo GW.
europepmc   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1212-1224, June 2026.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

Assessing Molecular Dynamics in Predicting Aptamer-Ligand Binding Thermodynamics: Insights from the OTA Binding Aptamers. [PDF]

J Chem Inf Model
Olivieri A, Borzelli F, Giustini M, D'Abramo M.   +3 more
europepmc   +1 more source

Advances and challenges in multiscale biomolecular simulations: artificial intelligence‐driven paradigm shift

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Molecular simulation techniques have become an invaluable tool for elucidating the fundamental principles of life at the molecular level. After nearly five decades of development, biomolecular simulations have evolved to enable the quantitative characterization of complex biomolecular events, such as protein folding, conformational dynamics ...
Wenfei Li, Wei Wang
wiley   +1 more source

How Binding Affinity and Binding Specificity Map to Sequence Space. [PDF]

J Mol Evol
Liberles DA, Meyer MM.
europepmc   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]

J Phys Chem B
Olivieri A, Nardi AN, D'Abramo M.
europepmc   +1 more source

LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3597-3615, June 2026.
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro, Alba López‐Laguna, Dolores Férnandez‐Ortuño, Alejandro Pérez‐García, Álvaro Polonio   +4 more
wiley   +1 more source

ASOG: AntiSense Oligonucleotide Generator. [PDF]

Comput Struct Biotechnol J
Kimi J, Korczak P, Vialet B, Roubin E, Barthélémy P, Campagne S, Malard F.   +6 more
europepmc   +1 more source

Systemic Delivery of Functional Proteins Into Plants Using an Engineered Membrane Translocation Domain

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3939-3952, June 2026.
ABSTRACT Protein‐based biopesticides and biostimulants are critical for the future of sustainable agriculture, yet their utility is severely limited by inefficient delivery into plant cells. Traditional cell‐penetrating peptides enable protein uptake but lack the efficiency, systemic activity and scalability required for crop production.
Jiyang Wang, Preeti Patel, Prabhat Bhat, Cailin Hu, Cameron Storch, Brendan Harty, Maria Bellizzi, Colton Jordan, Devin Good, Venkat Gopalan, Jonathan Michael Jacobs, Dehua Pei, Guo‐Liang Wang   +12 more
wiley   +1 more source