Results 21 to 30 of about 10,354 (218)
Thermodynamic database for protein-nucleic acid interactions
Seibutsu Butsuri, 2000 Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding.
Prabakaran, P. +6 more
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Native characterization of nucleic acid motif thermodynamics via non-covalent catalysis
Nature Communications, 2016 DNA hybridisation thermodynamics parameters underlie rational design of oligonucleotides for diagnostics and nanotechnology. Here, the authors present an accurate method to measure the free energy of a given DNA structure at specific temperature and ...
Chunyan Wang, Jin H. Bae, David Yu Zhang
doaj +1 more source
Scalable Indirect Free Energy Method Applied to Divalent Cation-Metalloprotein Binding
, 2019 Many biological processes are based on molecular recognition between highly charged molecules such as nucleic acids, inorganic ions, charged amino acids, etc.
Jacob Litman (6910517) +2 more
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BioTechniques, 2008 A rapid capture technique was developed to efficiently isolate specific DNA targets from a variety of genomes. The specificity can be easily adapted to any target for which partial sequence is known, allowing for the isolation of a wide set of target ...
Judy St. John, Thomas W. Quinn
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An efficient algorithm for the stochastic simulation of the hybridization of DNA to microarrays
BMC Bioinformatics, 2009 Background Although oligonucleotide microarray technology is ubiquitous in genomic research, reproducibility and standardization of expression measurements still concern many researchers. Cross-hybridization between microarray probes and non-target ssDNA
Laurenzi Ian J, Arslan Erdem
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Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides [PDF]
Nucleic Acids Research, 2010 Thermodynamics provides insights into the influence of modified nucleotide residues on stability of nucleic acids and is crucial for designing duplexes with given properties. In this article, we introduce detailed thermodynamic analysis of RNA duplexes modified with unlocked nucleic acid (UNA) nucleotide residues.
Pasternak, Anna, Wengel, Jesper
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BMC Bioinformatics, 2007 Background RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathways.
Peek Andrew S
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Modified RNA triplexes: Thermodynamics, structure and biological potential
Scientific Reports, 2018 The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation of these structures is the result of conformational changes that occur in the duplex, which allow the ...
Marta Szabat +2 more
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LiquidsThis article presents a mini-review of the available data on the thermodynamics of the complexation of amino acids and peptides with some nucleic bases in a buffer medium.
Elena Yu. Tyunina +2 more
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AnglerFISH Enables the Design of smFISH Probes Targeting Conserved Transcripts
, 2022 Single-molecule fluorescence in situ hybridization (smFISH) is a powerful tool to visualize individual nucleic acid molecules in biological samples. smFISH functions via the principles of nucleic acid thermodynamics where two complementary strands anneal
Davis, Sachin
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