Results 31 to 40 of about 2,687,425 (254)

CRISPR-based nucleic acid diagnostics for pathogens [PDF]

, 2022
Pathogenic infections remain the primary threat for human health, especially the global COVID-19 pandemic. It is important to develop rapid, sensitive and multiplexed tools for detecting pathogens and their mutations, particularly the tailor-made ...
Yong, Zhang, Ruijie, Deng, Jinghong, Li, Hao, Yang, Xucong, Teng, Hongwei, Hou   +5 more
core   +1 more source

Design principles for ligand-sensing, conformation-switching ribozymes. [PDF]

PLoS Computational Biology, 2009
Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications. A number of ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes) have been generated by some ...
Xi Chen, Andrew D Ellington
doaj   +1 more source

Thermodynamic database for protein–nucleic acid interactions (ProNIT) [PDF]

Bioinformatics, 2001
Abstract Motivation: Protein–nucleic acid interactions are fundamental to the regulation of gene expression. In order to elucidate the molecular mechanism of protein–nucleic acid recognition and analyze the gene regulation network, not only structural data but also quantitative binding data are necessary.
Ponraj Prabakaran, Jianghong An, M. Michael Gromiha, Samuel Selvaraj, Hatsuho Uedaira, Hidetoshi Kono, Akinori Sarai   +6 more
openaire   +2 more sources

Viral genome structures are optimal for capsid assembly

eLife, 2013
Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications.
Jason D Perlmutter, Cong Qiao, Michael F Hagan   +2 more
doaj   +1 more source

Nucleic acid-lipid membrane interactions studied by DSC

Journal of Pharmacy and Bioallied Sciences, 2011
The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely
Sarantis Giatrellis, George Nounesis
doaj   +1 more source

Thermodynamic database for protein-nucleic acid interactions

Seibutsu Butsuri, 2000
Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding.
Prabakaran, P., An, Jianghong, Gromiha, M. Michael, Selvaraj, S., Uedaira, Hatsuho, Kono, Hidetoshi, Sarai, Akinori   +6 more
openaire   +2 more sources

Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]

, 1968
With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core   +1 more source

Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]

, 2013
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
Carlon, E, Buhot, A, Hooyberghs, J, Harrison, A., Gamble, LJ, Pozhitkov, A., Pettitt, B., Tautz, D. ; https://orcid.org/, Levicky, Rastislav, Harrison, A, Buhot, A., Carlon, E., Pozhitkov, Alexander E, Gibas, C, Halperin, A, Binder, H, Pettitt, BM, Gamble, L., Noble, P., Hooyberghs, Jef, Harrison, Andrew B., Levicky, R, Pettitt, B. Montgomery, Pozhitkov, AE, Noble, PA, Carlon, Enrico, Halperin, Avraham, Kreil, David P, Levicky, R., Ott, A, Kreil, DP, Tautz, Diethard, Binder, H., Halperin, A., Burden, Conrad John, Gibas, Cynthia, Burden, CJ, Burden, Conrad J, Kreil, David, Hooyberghs, J., Buhot, Arnaud, Gamble, Lara J., Noble, Peter A, Harrison, Andrew, Gamble, Lara J, Tautz, D, Pettitt, B Montgomery, Kreil, D., Ott, A., Binder, Hans, Burden, C., Ott, Albrecht, Pozhitkov, Alexander E., Gibas, C., Noble, Peter A.   +54 more
core   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM) [PDF]

, 2003
Pyrrolidine-amide oligonucleotide mimics (POM) 1 were designed to be stereochemically and conformationally similar to natural nucleic acids, but with an oppositely charged, cationic backbone.
Tan, T. H. Samuel, Morral, Jordi, Tan, T.H.S., Morral-Cardoner, Jordi, Micklefield, Jason, Cooper, M.A., Hickman, D. T., Micklefield, J., Morral, J., King, Paul M., Hickman, David T., Cooper, Matthew A., King, P.M., Hickman, D.T., Samuel Tan, T. H.   +14 more
core   +1 more source