Results 51 to 60 of about 34,814 (245)

The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]

, 2017
This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
core   +2 more sources

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Magnetic Droplet Manipulation on Open Surfaces

Advanced Materials Technologies, EarlyView.
Recent advances in the manipulation of magnetic droplets demonstrate various manipulations on open surfaces, including transport, splitting, merging, and force‐controlled motion, enabled by magnetic particles and external fields. ABSTRACT Manipulation of liquids on a smaller scale enables applications in various fields, particularly diagnostics and ...
Robab Jahangir, Vahid Nasirimarekani
wiley   +1 more source

Expanding the Functions of KHSRP Protein: Insights into DNA G‐Quadruplex Binding

Advanced Science
KHSRP (KH‐type splicing regulatory protein) is a multifunctional nucleic acid‐binding protein that regulates various cellular processes, with critical roles in controlling gene expression.
Pasquale Russomanno, Pasquale Zizza, Linda Cerofolini, Federica D'Aria, Sara Iachettini, Serena Di Vito, Annamaria Biroccio, Jussara Amato, Marco Fragai, Bruno Pagano   +9 more
doaj   +1 more source

Salt Effects on the Thermodynamics of a Frameshifting RNA Pseudoknot under Tension

, 2016
Because of the potential link between -1 programmed ribosomal frameshifting and response of a pseudoknot (PK) RNA to force, a number of single molecule pulling experiments have been performed on PKs to decipher the mechanism of programmed ribosomal ...
Denesyuk, Natalia A., Hori, Naoto, Thirumalai, D.   +2 more
core   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection

Advanced Science, EarlyView.
A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang, Jiahao Li, Zhuying Yue, Beixuan He, Wenhua Zhang, Zhen Fang, Qing Xia, Yingbin Liu, Yanjing Li   +8 more
wiley   +1 more source

Theory on the mechanism of DNA renaturation: Stochastic nucleation and zipping

, 2015
Renaturation of complementary single strands of DNA is one of the important processes that requires better understanding in the view of molecular biology and biological physics.
Murugan, Rajamanickam, Niranjani, Gnanapragasam   +1 more
core   +2 more sources

Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A [PDF]

, 2011
DNA-sequence and structure dependence on the formation of minor groove complexes at 5′-XCTAGY-3′ by the short lexitropsin thiazotropsin A are explored based on NMR spectroscopy, isothermal titration calorimetry (ITC), circular dichroism (CD) and ...
Anthony, Anthony, Anthony, Barber, Bergqvist, Blaskó, Borea, Chaires, Chenoweth, Dervan, Dervan, Engel, Freyer, Freyer, Gottesfeld, Haq, Haq, Harris, James, Khalaf, Kwong, Ladbury, Lafont, Marques, Neidle, O'Brien, Pang, Parkinson, Pelton, Pullman, Rodger, Schwabe, Spolar, Suckling, Trauger, Treesuwan, Wemmer, Wemmer, Wittayanarakul   +38 more
core   +2 more sources

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source