Results 71 to 80 of about 2,687,425 (254)
Angewandte Chemie, EarlyView.DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base‐pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first‐formed interactions biasing the final morphology: short hydrophobic chain strands form DX‐tiles and then into stars, while long‐chain strands form SNAs and ...
Yihao Wu +3 more
wiley +2 more sources
Nature CommunicationsRNA–RNA interactions (RRIs) are fundamental to gene regulation and RNA processing, yet their molecular determinants remain unclear. In this work, we analyze several large-scale RRI datasets and identify low-complexity repeats (LCRs), including simple ...
Adriano Setti +14 more
doaj +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
New peptide nucleic acids for biotechnological applications [PDF]
, 2010 In the present study was designed and realized a new similar to the PNA. It is a chiral nucleo-γ-peptide, dabPNA, isomer of the aegPNA unit and characterized by a 2,4-diaminobutyric acid (DABA)-based backbone carrying the carboxymethylated nucleobase on ...
Castiglione, Mariangela
core +1 more source
Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors
Angewandte Chemie, EarlyView.A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma +10 more
wiley +2 more sources
Artificial Intelligence for Nucleic Acid Aptamers: Methods and Applications
Shengwu huaxue yu shengwu wuli jinzhanNucleic acid aptamers represent a class of single-stranded oligonucleotides capable of high-affinity and specific binding to diverse targets, including proteins, small molecules, cells, and metal ions.
LIU Shang-Hua +7 more
doaj +1 more source
Advanced Science, EarlyView.Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva +7 more
wiley +1 more source
Dynamic Operations in Macromolecular Data Storage
Angewandte Chemie, EarlyView.With the exponential growth of digital data and the limitations of conventional silicon‐based storage and computing technologies, macromolecular data storage, the practice of encoding digital information within large, complex molecules like DNA or synthetic polymers, has emerged as a scalable and sustainable alternative to traditional digital ...
Jakub Ossowski +3 more
wiley +2 more sources
Microfluidic-Based Nucleic Acid Amplification Systems in Microbiology
, 2019 Rapid, sensitive, and selective bacterial detection is a hot topic, because the progress in this research area has had a broad range of applications.
Stratton, Helen +5 more
core +1 more source
Advanced Science, EarlyView.An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li +15 more
wiley +1 more source