Results 161 to 170 of about 954,039 (243)

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Non-Viral Delivery Systems to Transport Nucleic Acids for Inherited Retinal Disorders. [PDF]

Pharmaceuticals (Basel)
Jony MJ, Joshi A, Dash A, Shukla S.
europepmc   +1 more source

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING

Advanced Science, EarlyView.
Based on IP‐MS analysis, BAG2 is confirmed to be essential for ubiquitination and protein homeostasis regulation of STING in cervical cancer. BAG2 inhibits the ubiquitination and degradation of STING by forming a complex with STUB1, thereby activating the type I IFN signaling pathway and inhibiting the development of cervical cancer.
Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, Hongbing Cai   +6 more
wiley   +1 more source

Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids. [PDF]

Molecules
Allen R, Yokota T.
europepmc   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Optimising in-cell NMR acquisition for nucleic acids. [PDF]

J Biomol NMR
Annecke HTP, Eidelpes R, Feyrer H, Ilgen J, Gürdap CO, Dasgupta R, Petzold K.   +6 more
europepmc   +1 more source

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Advanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin‐yu Chen, Chunhua Li, Lixin Ma   +11 more
wiley   +1 more source

FRET-guided modeling of nucleic acids. [PDF]

Nucleic Acids Res
Steffen FD, Cunha RA, Sigel RKO, Börner R.   +3 more
europepmc   +1 more source

Nanoparticle Delivery of Antisense miR162 Inhibits Invasive Habitat Adaption of Alternanthera Philoxeroides

Advanced Science, EarlyView.
This study demonstrates that the miRNA pathway plays a key role in the invasive growth of Alternanthera philoxeroides in aquatic habitats. Specifically, miR162 is critical for its invasive success, facilitating stem elongation and enhancing survival during submergence.
Qianqian Hu, Erfeng Kou, Xiuzhen Liao, Ruiyi Qiu, Qi Tang, Huan Zhang, Yun Zheng, Ji Yang, Binglian Zheng   +8 more
wiley   +1 more source

SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity. [PDF]

Nat Commun
Hou G, Beatty W, Ren L, Ooi YS, Son J, Zhu Y, Sheng Q, Huang W, Li D, Liu C, Welsh OL, Sutherland DM, Dermody TS, Shen C, Liu J, Sibley LD, Ding S.   +16 more
europepmc   +1 more source