Results 331 to 340 of about 6,062,195 (387)
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Nucleic acids delivering nucleic acids
Advanced Drug Delivery Reviews, 2018Nucleic acid therapeutics, including siRNAs, miRNAs/antimiRs, gRNAs and ASO, represent innovative and highly promising molecules for the safe treatment of a wide range of pathologies. The efficiency of systemic treatments is impeded by 1) the need to overcome physical and functional barriers in the organism, and 2) to accumulate in the intracellular ...
S. Catuogno +3 more
semanticscholar +6 more sources
Polymeric Delivery of Therapeutic Nucleic Acids.
Chemical Reviews, 2021The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising.
Ramya Kumar +8 more
semanticscholar +1 more source
Annual Review of Biochemistry, 1957
Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Recent work in the fields of nucleic acid structure, the relation of nucleic acids to physiological and metabolic events, and biological interventions are summarized. (C.H.)
E. Volkin, W.E. Cohn
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Journal of the American Chemical Society, 2012
A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
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A historical perspective of the development of spherical nucleic acid (SNA) conjugates and other three-dimensional nucleic acid nanostructures is provided. This Perspective details the synthetic methods for preparing them, followed by a discussion of their unique properties and theoretical and experimental models for understanding them.
Chad A. Mirkin +2 more
openaire +3 more sources
Acta Crystallographica Section D Biological Crystallography, 2002
The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
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The Nucleic Acid Database was established in 1991 as a resource to assemble and distribute structural information about nucleic acids. Over the years, the NDB has developed generalized software for processing, archiving, querying and distributing structural data for nucleic acid-containing structures.
B. Schneider +9 more
openaire +5 more sources
Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins.
Chemical Reviews, 2019Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently reacting with cellular constituents. The resulting oxidatively generated damage to nucleic acids, membrane unsaturated lipids, and protein components has been ...
P. Di Mascio +5 more
semanticscholar +1 more source
Current Opinion in Biotechnology, 2005
Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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Since the discovery of the first natural ribozyme more than 20 years ago, it has become clear that nucleic acids are not only the static depository of genetic information, but also possess intriguing catalytic activity. The number of reactions catalyzed by engineered nucleic acid enzymes is growing continuously.
Fiammengo, R., Jaschke, A.
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Angewandte Chemie, 2018
Isothermal exponential amplification techniques, such as strand-displacement amplification (SDA), rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP), nucleic acid sequence based amplification (NASBA), helicase-dependent ...
Michael S. Reid +2 more
semanticscholar +1 more source
Isothermal exponential amplification techniques, such as strand-displacement amplification (SDA), rolling circle amplification (RCA), loop-mediated isothermal amplification (LAMP), nucleic acid sequence based amplification (NASBA), helicase-dependent ...
Michael S. Reid +2 more
semanticscholar +1 more source
2017
Nucleic acids (NA) contain the genetic information and play a key role in protein biosynthesis. They are formed by the polymerization of units called nucleotides, which consist of a nitrogenous base, an aldopentose, and phosphoric acid. The base can be a pyrimidine: thymine (T), cytosine (C), and uracil (U); or a purine: adenine (A) and guanine (G ...
Antonio Blanco, Gustavo Blanco
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Nucleic acids (NA) contain the genetic information and play a key role in protein biosynthesis. They are formed by the polymerization of units called nucleotides, which consist of a nitrogenous base, an aldopentose, and phosphoric acid. The base can be a pyrimidine: thymine (T), cytosine (C), and uracil (U); or a purine: adenine (A) and guanine (G ...
Antonio Blanco, Gustavo Blanco
openaire +2 more sources