Results 191 to 200 of about 62,842 (285)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators. [PDF]

Cells
Muñoz López M, López-Gil JF, Ramírez de la Piscina Viúdez X, Baz-Valle E, Tornero Aguilera JF.   +4 more
europepmc   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, EarlyView.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

Identification of the nucleolar localization signal in <i>Autographa californica</i> multiple nucleopolyhedrovirus multifunctional protein Ac16. [PDF]

J Gen Virol
Chen G, Wu Y, Yang J, Wang H, Zhang X, Feng G.   +5 more
europepmc   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Tuning nuclear rheology through transient chromatin cross-links. [PDF]

Phys Rev E
Zhang YD, Wu CH, Shi HX, Merlitz H, Bloom KS, Forest MG, Wu CX, Cao XZ.   +7 more
europepmc   +1 more source

Updates and controversies in contemporary grading of clear cell renal cell carcinoma and papillary renal cell carcinoma

Histopathology, EarlyView.
New concepts, innovations and some issues have emerged since the adoption a decade ago of WHO/ISUP grading for CCRCC and PRCC. Continued use of the WHO/ISUP grading for CCRCC and PRCC has been upheld by newer studies, and practice guidance for some of the grading issues, where data are available, is provided.
Gladell P. Paner, Mahul. B. Amin, Jung Woo Kwon, Liang Cheng, Holger Moch   +4 more
wiley   +1 more source

Labeling of nascent RNA in the C. elegans intestine. [PDF]

PLoS One
Gholamalamdari O, Weber SC.
europepmc   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

Reversible Nucleolar Complex Coacervation by Short Cationic Peptides. [PDF]

J Am Chem Soc
Schuler M, Koca E, Driehaus-Ortiz L, Braun MG, Lahu A, Holtmannspötter AL, Nguyen HC, Boekhoven J, Ng DYW, Weil T.   +9 more
europepmc   +1 more source