An exceptional fluorescence turn-on nucleoside: Lighting up single-stranded DNA with constant brightness regardless neighboring bases [PDF]
Fluorescent nucleobase analogs (FBAs) have proven valuable for studying nucleic acid structure and dynamics. Regrettably, most FBAs exhibit reduced quantum yields when incorporated into DNA, particularly when neighboring residues are present.
Xiaoluo, Huang +8 more
core +1 more source
Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill
Beilstein Journal of Organic Chemistry, 2017 Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes.
Olga Eguaogie +8 more
doaj +1 more source
Bis(benzoyloxybenzyl)-DiPPro Nucleoside Diphosphates of Anti-HIV Active Nucleoside Analogues [PDF]
, 2015 Nucleoside analogues are extensively used as antiviral and anticancer agents. Their efficiency is dependent on their metabolism into the ultimately active nucleoside triphosphates.
Schols, Dominique +4 more
core +1 more source
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
Angewandte Chemie International Edition, EarlyView.Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber +4 more
wiley +1 more source
Antiretoviral therapy and the lipodystrophy syndrome, part 2: Concepts in aetiopathogenesis [PDF]
, 2001 Clinical research has indicated that the use of nucleoside reverse transcriptase inhibitor (NRTI) and HIV protease inhibitor (PI) therapy is associated with a risk of long-term toxicity syndromes, and that the aetiopathogenesis of these adverse effects ...
Nolan, D., John, M., Mallal, S.
core +1 more source
Biocatalytic transformation of nucleoside derivatives [PDF]
, 2010 Nucleoside derivatives are a class of compounds that have attracted intense interest in biotechnology and medicine. Use of biocatalysts opens exciting opportunities for selective synthesis of many nucleoside derivatives, and such an approach offers ...
Smith, T. J., Zong, M. H., Li, N.
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Prevalence of nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations. [PDF]
, 2019 Prevalence of nucleoside reverse transcriptase inhibitor (NRTI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations.
Damian Nota Anong (4911604) +6 more
core +1 more source
Sensors, 2016 Cancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and ...
Corinne Dejous +8 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini +19 more
wiley +1 more source