Results 51 to 60 of about 2,664 (174)
Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine [PDF]
, 2014 Described here are mechanistic details of the chemical reactivities of two modified/saturated pyrimidine residues that represent naturally occurring forms of DNA damage: 5-thyminyl-5,6-dihydrothymine, commonly referred to as the “spore photoproduct” (
Dria, Karl J. +4 more
core +3 more sources
Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.
Journal of Biological Chemistry, 1984 The nature of the interaction between Escherichia coli cytidine deaminase and the phosphapyrimidine nucleoside 1 has been studied kinetically and spectrophotometrically. Compound 1 was designed as a transition-state analog, and is a potent, slow-binding inhibitor of cytidine deaminase (Ashley, G. W., and Bartlett, P. A. (1982) Biochem. Biophys.
G W, Ashley, P A, Bartlett
openaire +2 more sources
Endonuclease V: From Transcriptome Regulator to Chemical Biology Tool
ChemistryEurope, Volume 4, Issue 2, February 2026.Post‐transcriptional modifications play a pivotal role in regulating the health and physiology of human cells, and adenosine‐to‐inosine (A‐to‐I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery, and this change impacts both the regulation and genetic code of RNA, in turn effectively ...
Prasanth Thota +5 more
wiley +1 more source
, 2014 The standard of care for patients suffering cancer often includes treatment with nucleoside analogues (NAs). NAs are internalized by cell-specific nucleobase/nucleoside transporters and, after enzymatic activation (often one or more phosphorylation steps)
Balzarini, Jan +2 more
core
Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.Abstract This Phase 1 study investigated the pharmacokinetics and safety of a single dose of the FDA‐approved doxecitine and doxribtimine (266.6 mg/kg; 133.3 mg/kg of deoxycytidine [dC] and deoxythymidine [dT]) in participants with severe (n = 8) or moderate (n = 8) renal impairment (estimated glomerular filtration rate [eGFR] 15–29 mL/min/1.73 m2 and ...
Aravind Mittur, Susan A. VanMeter
wiley +1 more source
The metagenomic telescope. [PDF]
, 2014 Next generation sequencing technologies led to the discovery of numerous new microbe species in diverse environmental samples. Some of the new species contain genes never encountered before.
G. Vértessy, Beáta +4 more
core +3 more sources
In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters
The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou +9 more
wiley +1 more source
Sampling protein motion and solvent effect during ligand binding. [PDF]
, 2012 An exhaustive description of the molecular recognition mechanism between a ligand and its biological target is of great value because it provides the opportunity for an exogenous control of the related process.
C. L. Motta +8 more
core +1 more source
Microbial Biotechnology, Volume 19, Issue 2, February 2026.Chronic Spontaneous Urticaria (CSU) is linked to gut dysbiosis and elevated serum uric acid/hypoxanthine. Lactobacillus paragasseri LG‐1 alleviates urticaria by degrading these metabolites, inhibiting TLR4‐NF‐κB inflammation, and remodelling gut microbiota.
Qiong Wang +8 more
wiley +1 more source
DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source