Results 41 to 50 of about 2,664 (174)

Life without dUTPase [PDF]

, 2016
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of Deoxyribonucleic Acid (DNA). The genetic information is also safeguarded by DNA damage recognition and repair processes.
Altschul, Bjornberg, Bohr, Boshoff, Castillo-Acosta, Castillo-Acosta, Chen, Chen, Cole, Cone, Dengg, el-Hajj, Galperin, Golding, Goncalves, Helt, Hogrefe, Huffman, Huson, Jiricny, Kana, Kiljunen, Kunkel, Lindahl, Lu, Meier, Merenyi, Minton, Mir-Sanchis, Moroz, Muha, Nagy, Nelson, Novick, Peacock, Pecsi, Rona, Serrano-Heras, Serrano-Heras, Sire, Szabo, Takahashi, Uchiyama, Vertessy, Visnes, Wang, Wang, Wang, Weil   +48 more
core   +2 more sources

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, Volume 13, Issue 17, 23 March 2026.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Genetic variability in adenosine deaminase-like contributes to variation in alcohol preference in mice. [PDF]

, 2017
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2.
Bailey, A, Lesscher, HMB, Vanderschuren, LJMJ   +2 more
core   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

Reactive species and DNA damage in chronic inflammation: Reconciling chemical mechanisms and biological fates [PDF]

, 2010
Chronic inflammation has long been recognized as a risk factor for many human cancers. One mechanistic link between inflammation and cancer involves the generation of nitric oxide, superoxide and other reactive oxygen and nitrogen species by macrophages ...
Anant, Asahi, Asaka, Badawi, Badouard, Balkwill, Barnes, Bartsch, Blair, Blair, Bouvard, Bredt, Broedbaek, Budiawan, Buettner, Cary, Chaudhuri, Chen, Chen, Cho, Cho, Chung, Chung, Chung, Chung, Colotta, Cooke, Cooke, Coussens, David, Dechakhamphu, Dechakhamphu, Dedon, Dedon, Dedon, Dong, Dong, Douki, Douki, Ebert, EESCoOD, Eiserich, Evans, Farrell, Flores-Santana, Friedman, Glaser, Godschalk, Groopman, Gross, Hailer, Halliwell, Harris, Hazen, Hazen, Henderson, Herszenyi, Hillestrom, Hirst, Hoberg, Holmgren, Hoopengardner, Huang, Hughes, Hussain, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Itzkowitz, Jeong, Keegan, Knutson, Knutson, Knutson, Kozekov, Lancaster, Lee, Lewis, Lim, Lima, MacMicking, Mancardi, Mao, Marnett, Marnett, Marnett, Marnett, Masuda, Maynard, Meerang, Minko, Miwa, Moncada, Mossman, Mossman, Mostafa, Nair, Nair, Nair, Nathan, Nathan, Nelson, Ohshima, Ohshima, Olliver, Otteneder, Pan, Pang, Pawlowicz, Paz-Elizur, Pham, Plastaras, Plastaras, Pouget, Reuter, Reynaud, Riggins, Riggins, Sanchez, Sawa, Schnetz-Boutaud, Schnetz-Boutaud, Schottenfeld, Seril, Shafirovich, Shapiro, Shapiro, Shen, Shigenaga, Sripa, Steenken, Stone, Stuehr, Suzuki, Suzuki, Tan, Thomas, Thun, Turney, Uppu, van der Vliet, Virchow, Visconti, Visnes, Wang, Whitcomb, Wink, Wink, Winter, Wu, Yanagawa, Yonekura, Zhang, Zhang, Zhou   +152 more
core   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Chromatin Accessibility in Cancer: Biological Functions, Mechanisms, Therapeutic Potential, and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia, Min Jiang, Yefei Huang, Kun Ding, Yansu Chen   +4 more
wiley   +1 more source

In-vivo mutation rates and fitness landscape of HIV-1

, 2016
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection, we
Albert, Jan, Brodin, Johanna, Neher, Richard, Puller, Vadim, Zanini, Fabio   +4 more
core   +1 more source

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes.
Mourad Mseddi, Christa Nath, Khalil Ben Hassine, Vid Mlakar, Yvonne Gloor, Fanny Gonzales, Chakradhara Rao S. Uppugunduri, Youssef Daali, Steven Keogh, Marc Ansari   +9 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source