Results 21 to 30 of about 1,562 (132)
British Journal of Pharmacology, EarlyView.Background and Purpose Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach The expression of adenosine receptors was measured by qRT‐PCR.
András Harazin +10 more
wiley +1 more source
Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.
Journal of Biological Chemistry, 1984 The nature of the interaction between Escherichia coli cytidine deaminase and the phosphapyrimidine nucleoside 1 has been studied kinetically and spectrophotometrically. Compound 1 was designed as a transition-state analog, and is a potent, slow-binding inhibitor of cytidine deaminase (Ashley, G. W., and Bartlett, P. A. (1982) Biochem. Biophys.
G W, Ashley, P A, Bartlett
openaire +2 more sources
Combined familial adenosine deaminase and purine nucleoside phosphorylase deficiencies. [PDF]
Archives of Disease in Childhood, 1988 We studied an Arab family in which two infants died of severe combined immunodeficiency caused by adenosine deaminase (ADA) deficiency. One infant had purine nucleoside phosphorylase (PNP) activity in the leucocytes only half that of normal. Four other infant siblings had previously died from infections before the age of 2 months.
A, Shanon +4 more
openaire +2 more sources
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli +12 more
wiley +1 more source
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s) [PDF]
Proceedings of the National Academy of Sciences, 1977 Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems.
D A, Carson, J, Kaye, J E, Seegmiller
openaire +2 more sources
MicrobiologyOpen, Volume 15, Issue 3, June 2026.A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres +13 more
wiley +1 more source
Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real‐World Data
Clinical and Translational Science, Volume 19, Issue 6, June 2026.ABSTRACT Xanthine oxidase (XO) inhibitors remain the standard pharmacologic therapy for hyperuricemia. However, additional enzymatic components of the purine degradation pathway may contribute to uric acid synthesis. Guanine deaminase (GD) catalyzes the conversion of guanine to xanthine, providing substrate for downstream oxidation by XO.
Joseph Magagnoli +5 more
wiley +1 more source
Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu +4 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Protective mechanisms of Camellia oleifera seed cake extract (SCE) against hyperuricemia and renal injury via modulation of uric acid metabolism, Nrf2/Keap1 signaling, and NLRP3 inflammasome activation. ABSTRACT Camellia oleifera seed cake is a major byproduct of the oil industry, often underutilized despite its richness in bioactive compounds.
Liting Mai +10 more
wiley +1 more source