Results 11 to 20 of about 1,595 (133)

Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse [PDF]

Journal of Clinical Investigation, 1970
The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen.
Rothman, I K, Zanjani, E D, Gordon, A S, Silber, R   +3 more
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Dextran-Linked Purine Nucleosides as Substrates and Inhibitors of Adenosine Deaminase [PDF]

European Journal of Biochemistry, 1982
Dextran-bound adenosine, inosine, and nebularine have been prepared by carbodiimide coupling of their 2',3'-O-(4-carboxyethyl-1-methylbutylidene) cyclic acetal derivatives to 6-aminohexyldextran or 12-aminododecanyldextran. The latter polymers were prepared by cyanogen-bromide activation of dextran T80 followed by reaction with 1,6-diaminohexane or 1 ...
H, Rosemeyer, E, Körnig, F, Seela
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Increased Excretion of Modified Adenine Nucleosides by Children with Adenosine Deaminase Deficiency [PDF]

Pediatric Research, 1982
We have identified seven adenine nucleosides in urines of untreated adenosine deaminase (ADA) deficient patients, four of which (adenosine, 2'-deoxyadenosine, 1-methyladenosine and N6-methyladenosine) have been previously identified in urines of normals and/or ADA deficient patients.
R, Hirschhorn, H, Ratech, A, Rubinstein, P, Papageorgiou, H, Kesarwala, E, Gelfand, V, Roegner-Maniscalco   +6 more
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Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

Delineation of the Molecular Mechanisms of Nucleoside Recognition by Cytidine Deaminase through Virtual Screening [PDF]

ChemMedChem, 2011
AbstractCytidine deaminase (EC 3.5.4.5, CDA), an enzyme of the pyrimidine salvage pathways, is responsible for the degradation and inactivation of several cytidine‐based antitumor drugs such as cytarabine, gemcitabine, decitabine, and azacytidine. Thus, CDA inhibitors are highly sought after as compounds to be co‐administered with said drugs to improve
COSTANZI, Stefano, Vilar S, Micozzi D, CARPI, FRANCESCO MARTINO, Ferino G, VITA, Alberto, VINCENZETTI, Silvia   +6 more
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Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, EarlyView.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Inhibition of Escherichia coli cytidine deaminase by a phosphapyrimidine nucleoside.

Journal of Biological Chemistry, 1984
The nature of the interaction between Escherichia coli cytidine deaminase and the phosphapyrimidine nucleoside 1 has been studied kinetically and spectrophotometrically. Compound 1 was designed as a transition-state analog, and is a potent, slow-binding inhibitor of cytidine deaminase (Ashley, G. W., and Bartlett, P. A. (1982) Biochem. Biophys.
G W, Ashley, P A, Bartlett
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Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s) [PDF]

Proceedings of the National Academy of Sciences, 1977
Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems.
D A, Carson, J, Kaye, J E, Seegmiller
openaire   +2 more sources