Results 1 to 10 of about 2,664 (174)

Nucleoside deaminases: the key players in base editing toolkit. [PDF]

Biophys Rep, 2023
The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision. Such nucleoside deaminases include adenosine and cytidine deaminases, which can catalyze adenosine-to-inosine (A-to-I) and cytidine-to-uridine (C-to-U) conversion respectively.
Xiang J, Xu W, Wu J, Luo Y, Yang B, Chen J.   +5 more
europepmc   +5 more sources

Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A [PDF]

Beilstein Journal of Organic Chemistry
Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine riboside was characterised as the most potent inhibitor of human CDA, but the quick ...
Maksim V. Kvach, Stefan Harjes, Harikrishnan M. Kurup, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev   +5 more
doaj   +2 more sources

Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5′-GA Sites [PDF]

Biomolecules
Adenosine Deaminases Acting on RNA (ADARs) are members of a family of RNA editing enzymes that catalyze the conversion of adenosine into inosine in double-stranded RNA (dsRNA).
Aashrita Manjunath, Jeff Cheng, Kristen B Campbell, Casey S. Jacobsen, Herra G. Mendoza, Leila Bierbaum, Victorio Jauregui-Matos, Erin E. Doherty, Andrew J. Fisher, Peter A. Beal   +9 more
doaj   +2 more sources

Sex Differences in Metabolite-Immune Circuits of Neuroinflammation. [PDF]

Immunol Rev
ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Saminathan P, Corey M, Gibbons A, Rayadurgam M, Reddy N, Ramesh P, Sharma S.   +6 more
europepmc   +2 more sources

Prokaryotic defense systems: Diversity and evolutionary adaptation. [PDF]

mLife
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Yang C, Gong L, Guo J, Xiang H.
europepmc   +2 more sources

Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme

mSphere, 2019
Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes, Víctor M. Castillo-Acosta, Maria Valente, Juana Carrero-Lérida, Guiomar Pérez-Moreno, Luis Miguel Ruiz-Pérez, Dolores González-Pacanowska   +6 more
doaj   +1 more source

Combined familial adenosine deaminase and purine nucleoside phosphorylase deficiencies. [PDF]

Archives of Disease in Childhood, 1988
We studied an Arab family in which two infants died of severe combined immunodeficiency caused by adenosine deaminase (ADA) deficiency. One infant had purine nucleoside phosphorylase (PNP) activity in the leucocytes only half that of normal. Four other infant siblings had previously died from infections before the age of 2 months.
A, Shanon, S, Levin, F, Holtzman, F, Brock-Sinai, A, Abu-Said   +4 more
openaire   +2 more sources

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes.

PLoS ONE, 2019
Oral administration of nucleotide analogues and injection of interferon-α (IFNα) are used to achieve immediate suppression in replication of hepatitis B virus (HBV).
Yutaka Furutani, Mariko Toguchi, Yumi Shiozaki-Sato, Xian-Yang Qin, Etsuko Ebisui, Shoko Higuchi, Masayuki Sudoh, Harukazu Suzuki, Nobuaki Takahashi, Koichi Watashi, Takaji Wakita, Hideaki Kakeya, Soichi Kojima   +12 more
doaj   +1 more source

Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse [PDF]

Journal of Clinical Investigation, 1970
The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10- to 100-fold) elevation of the enzyme activity occurred in the spleen.
Rothman, I K, Zanjani, E D, Gordon, A S, Silber, R   +3 more
openaire   +2 more sources

Dextran-Linked Purine Nucleosides as Substrates and Inhibitors of Adenosine Deaminase [PDF]

European Journal of Biochemistry, 1982
Dextran-bound adenosine, inosine, and nebularine have been prepared by carbodiimide coupling of their 2',3'-O-(4-carboxyethyl-1-methylbutylidene) cyclic acetal derivatives to 6-aminohexyldextran or 12-aminododecanyldextran. The latter polymers were prepared by cyanogen-bromide activation of dextran T80 followed by reaction with 1,6-diaminohexane or 1 ...
H, Rosemeyer, E, Körnig, F, Seela
openaire   +2 more sources