Results 1 to 10 of about 54,805 (241)

Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study [PDF]

, 2013
Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep.
A Alonso, A Khateb, A Serrano, AV Kalinchuk, AV Kalinchuk, AV Kalinchuk, BB Fredholm, BG Frenguelli, BP Klyuch, BP Klyuch, C Romano, C Xu, CF Hohmann, D Curran-Everett, D Lovatt, D Stenberg, DG Van Wylen, E Llaudet, E Murillo-Rodriguez, EA Newman, F Longordo, H McIlwain, HK Wigren, Houdini Ho Tin Wu, I Haulica, ID Manns, J Grivel, JB Mitchell, JC Hoffmann, JP Mothet, JT McKenna, JT Porter, LA Etherington, LI Kiyashchenko, LI Schmitt, LO Alanko, M Ballarin, M Radulovacki, M van den Top, M Wall, MA Greco, MG Lee, MJ Wall, MM Halassa, MM Halassa, MM Thakkar, MO Enkvist, Nicholas Dale, O Pascual, P Franken, P Maquet, R Basheer, R Basheer, R Basheer, R Shigemoto, RH Farkas, RM Virus, Robert Edward Sims, S Palchykova, SR Glaum, SR Ticho, T Porkka-Heiskanen, T Porkka-Heiskanen, T Porkka-Heiskanen, TE Bjorness, TR Minor, TV Dunwiddie, V Parpura, V Ramesh, Valérie Mongrain, VM Sciotti, WE Cullinan, ZL Huang   +72 more
core   +6 more sources

Adenosine deaminase, (ADA) level in leprosy

International Journal of Medicine and Health Development, 2012
Background: Adenosine deaminase (ADA) is involved in and the catabolism of toxic de-oxynucleotides (5) and modulation of insulin action. Although its activities in leprosy have been measured, its characteristics have not been reported.
I S I Ogbu, I N Nnatuanya, J C Onyeanusi
doaj   +1 more source

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors

Biomedicines, 2022
Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, Roberto Giovannoni, Ryszard T. Smolenski   +6 more
doaj   +1 more source

ADAR1 restricts LINE-1 retrotransposition [PDF]

, 2016
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects.
Antonioni, Ambra, Ciafré, Silvia Anna, Doria, Margherita, Frassinelli, Loredana, Galardi, Silvia, Mancone, Carmine, Michienzi, Alessandro, Montaldo, Claudia, Orecchini, Elisa, Tripodi, Marco   +9 more
core   +2 more sources

L-Arginine Intake Effect on Adenine Nucleotide Metabolism in Rat Parenchymal and Reproductive Tissues

The Scientific World Journal, 2012
L-arginine is conditionally essetcial amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence.
G. Kocic, J. Nikolic, T. Jevtovic-Stoimenov, D. Sokolovic, H. Kocic, T. Cvetkovic, D. Pavlovic, A. Cencic, D. Stojanovic   +8 more
doaj   +1 more source

The Diagnostic Efficacy of Adenosine Deaminase in Tubercular Effusion

Oman Medical Journal, 2013
Objective: This study aims to evaluate the diagnostic efficacy of adenosine deaminase in tubercular effusions.Methods: This study was conducted at the Department of General Medicine and Cardiovascular and Thoracic Surgery, SKIMS, for a period of two ...
Mohd Arif Kelam, Farooq Ahmad Ganie, Bashir Ahmad Shah, Shabir Ahmad Ganie, Mohd Lateef Wani, Nasir-U-Din Wani, Masaratul Gani   +6 more
doaj   +1 more source

Adenosine deaminase production by an endophytic bacterium (Lysinibacillus sp.) from Avicennia marina [PDF]

, 2013
The present study was carried out with the following objectives: (1) to isolate the endophytic bacilli strains from the leaves of mangrove plant Avicennia marina, (2) to screen the potential strains for the production of adenosine deaminase, (3) to ...
Kandasamy Kathiresan, Kandasamy Saravanakumar, Muthu Sivasankaran, Sunil Kumar Sahu   +3 more
core   +1 more source

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +1 more source

Dosagem da atividade da adenosina deaminase no líquido pleural para o diagnóstico da tuberculose pleural Pleural fluid adenosine deaminase detection for the diagnosis of pleural tuberculosis

Jornal Brasileiro de Pneumologia, 2004
INTRODUÇÃO: O diagnóstico da tuberculose pleural permanece um desafio, pois a sensibilidade dos testes tradicionais é baixa. O exame histopatológico da pleura é o método mais preciso, com até 80% de sensibilidade.
Morrys Casagrande Kaisemann, Afrânio Lineu Kritski, Maria de Fátima C Pereira, Anete Trajman   +3 more
doaj   +1 more source

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source