A hitchhiker's guide to single‐cell epigenomics: Methods and applications for cancer research
International Journal of Cancer, Volume 158, Issue 2, Page 291-304, 15 January 2026.Abstract Genetic mutations are well known to influence tumorigenesis, tumor progression, treatment response and relapse, but the role of epigenetic variation in cancer progression is still largely unexplored. The lack of epigenetic understanding in cancer evolution is in part due to the limited availability of methods to examine such a heterogeneous ...
Marta Moreno‐Gonzalez +2 more
wiley +1 more source
Comprehensive profiling of chromatin occupancy dynamics through the cell cycle. [PDF]
Nucleic Acids ResLi Y, MacAlpine DM, Hartemink AJ.
europepmc +1 more source
Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing. [PDF]
ElifeHughes AL +2 more
europepmc +1 more source
Enhancer‐dependent gene regulation in space, time, and malignancies
International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum +2 more
wiley +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Nucleosome Clustering as a Biomarker and Mechanistic Switch for Reprogramming Cells. [PDF]
CellsXu Z +5 more
europepmc +1 more source
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
Nature, 2020 Ting-Hai Xu +7 more
semanticscholar +1 more source
Epigenetic reprogramming in multiple myeloma—Challenges and opportunities
International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar +2 more
wiley +1 more source
Cryo-EM structures of NHEJ assemblies with nucleosomes. [PDF]
Nat CommunHall C +20 more
europepmc +1 more source