Results 221 to 230 of about 64,059 (299)

Antibody‐Nanoparticle Conjugates in Therapy: Combining the Best of Two Worlds

Small, Volume 21, Issue 15, April 16, 2025.
Antibody‐nanomaterial conjugates (ANCs) are an emerging therapeutic class combining the precise targeting specificity of antibodies with the versatility and functionality of nanomaterials. This review summarizes ANC design, synthesis, and potential therapeutic applications in this rapidly advancing field.
Aniruddha Adhikari, Irene A. Chen
wiley   +1 more source

Structure of the nucleosome-bound human BCL7A. [PDF]

Nucleic Acids Res
Martin F, Kazrani AA, Lafouge J, Diaz-Jimenez DM, Siebert S, Fabbro-Burtschell L, Maillard E, Lapouge K, Mertens HDT, Sauter C, Leitner A, Ochsenbein F, Blais A, Bergamin E.   +13 more
europepmc   +1 more source

Preferential Localization of a Subclass of Histone H1 on Nucleosomes Released byDigestion with DNase II

, 1981
Kei Takahashi, Yutaka Tashiro
openalex   +2 more sources

Transcriptional Potentiation of the Vitellogenin B1 Promoter by a Combination of Both Nucleosome Assembly and Transcription Factors: an In Vitro Dissection [PDF]

, 1990
Blaise Corthésy, Philippe Léonnard, Walter Wahli   +2 more
openalex   +1 more source

Reframing Formalin: A Molecular Opportunity Enabling Historical Epigenomics and Retrospective Gene Expression Studies

Molecular Ecology Resources, Volume 25, Issue 3, April 2025.
ABSTRACT Formalin preservation of museum specimens has long been considered a barrier to molecular research due to extensive crosslinking and chemical modification. However, recent optimisation of hot alkaline lysis and proteinase K digestion DNA extraction methods have enabled a growing number of studies to overcome these challenges and conduct genome‐
Clare E. Holleley, Erin E. Hahn
wiley   +1 more source

The Assembly of Regularly Spaced Nucleosomes in the Xenopus Oocyte S-150 Extract Is Accompanied by Deacetylation of Histone H4

, 1989
Akiko Shimamura, Abraham Worcel
openalex   +1 more source

Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders

Cell Proliferation, Volume 58, Issue 4, April 2025.
This review outlines the latest research advancements in prime editing technology, delivery strategies, and the challenges that must be addressed to fully realize its therapeutic potential, emphasizing the high potential of prime editing in the remission or cure of genetic diseases. ABSTRACT Genetic diseases have long posed significant challenges, with
Mengyao Li, Yi Lin, Qiang Cheng, Tuo Wei
wiley   +1 more source

Nucleosome wrapping states encode principles of 3D genome organization. [PDF]

Nat Commun
Wen Z, Fang R, Zhang R, Yu X, Zhou F, Long H.   +5 more
europepmc   +1 more source

Ribonucleotide-induced helical alteration in DNA prevents nucleosome formation.

, 1987
K R Hovatter, Harold G. Martinson
openalex   +1 more source

Chromosomal localization of PHOX2B during M‐phase is disrupted in disease‐associated mutants

Development, Growth &Differentiation, Volume 67, Issue 3, Page 136-148, April 2025.
Some transcription factors exhibit chromosomal localization during M‐phase and play an important role in the rapid re‐activation of target genes in early G1‐phase. In this study, we assessed the chromosomal localization of Paired‐like homeodomain 2B (PHOX2B) and its disease‐associated mutants, and found that disease‐associated PHOX2B mutants exhibited ...
Yuki Sato, Shinichi Hayashi, Souichi Oe, Taro Koike, Yousuke Nakano, Ryohei Seki‐Omura, Hikaru Iwashita, Yukie Hirahara, Masaaki Kitada   +8 more
wiley   +1 more source