Results 71 to 80 of about 33,576 (274)

Adenine nucleotide content and activity of AMP catabolism enzymes in the kidney of rats fed on diets with different protein and sucrose content

Біологічні студії
Background. Excessive consumption of sucrose or protein deficiency in the diet can induce metabolic disorders in the kidney, whose functioning requires significant ATP energy expenditure.
Halyna Kopylchuk, Oksana Voloshchuk
doaj   +1 more source

Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning. [PDF]

PLoS ONE, 2015
Adenosine is a powerful trigger for ischemic preconditioning (IPC). Myocardial ischemia induces intracellular and extracellular ATP degradation to adenosine, which then activates adenosine receptors and elicits cardioprotection.
Georg Wolff, Richard Truse, Ulrich Decking   +2 more
doaj   +1 more source

Efficient Gene Expression System in Medaka Embryos Enables Functional Characterization of nt5c1a Paralogs Involved in Inosine Monophosphate Metabolism

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Optimizing transient expression systems in fish embryos is crucial for rapid gene function analysis. Here, we established an efficient system in medaka (Oryzias latipes) embryos by evaluating nucleic acid type and injection site. Our results revealed that injecting the elongation factor 1αA (ef1αA) promoter‐driven plasmid into the yolk yielded
Yu Murakami, Tomohisa Horibe, Masashi Ando, Toru Kobayashi   +3 more
wiley   +1 more source

Features of the oxidation processes and state of microcirculatory channel have persons exposed to low doses of ionizing radiation

Бюллетень сибирской медицины, 2012
We have examined 36 liquidators (participants in emergency clean-up after the Chernobylnuclear accident) many years after the external γ-irradiation (on average (143.0 ± 14.0) mGy for (3.3 ± 0.8) months) and 13 workers of a typical research nuclear ...
Ya. V. Porovsky, T. V. Zhavoronok, N. V. Ryazntseva, F. F. Tetenev   +3 more
doaj   +1 more source

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000–2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis

Zoonoses and Public Health, Volume 73, Issue 4, Page 314-325, June 2026.
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Luciana de Freitas Campos Miranda, Laryssa Fabiano do Rosário Coelho, Samanta Cristina das Chagas Xavier, Artur Augusto Velho Mendes Junior, Renan Nunes Albuquerque, Aline Fagundes da Silva, Andreza Pain Marcelino, Fernanda Nunes Santos, Sandro Antonio Pereira, Rodrigo Caldas Menezes, Armando de Oliveira Schubach   +10 more
wiley   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, Volume 13, Issue 5, Page 1078-1083, May 2026.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Differential Adenosine Signaling and Effects of Acute Caffeine Exposure on Alternative Stress Coping Styles in Zebrafish (Danio rerio)

Brain and Behavior, Volume 16, Issue 5, May 2026.
Acute caffeine exposure exerts coping style‐ and sex‐dependent effects on anxiety‐like behavior in zebrafish, with reactive individuals, particularly males, showing the greatest sensitivity. The accompanying changes in adenosine receptor and adenosine deaminase expression demonstrate a possible molecular mechanism underlying these behavioral ...
Sydney E. Klucas, Ryan Y. Wong
wiley   +1 more source

Analysis of the NTPDase and ecto-5'-nucleotidase profiles in serum-limited Trichomonas vaginalis

Memorias do Instituto Oswaldo Cruz, 2012
Trichomonas vaginalis is a parasite of the human urogenital tract that causes trichomonosis, the most prevalent non-viral sexually transmitted disease. Ectonucleoside triphosphate diphosphohydrolase (NTPDase) family members, which hydrolyse extracellular
Amanda Piccoli Frasson, Mariele Feiffer Charão, Denis Broock Rosemberg, Ana Paula de Souza, Solange Cristina Garcia, Cristina Bonorino, Maurício Reis Bogo, Geraldo Attilio De Carli, Tiana Tasca   +8 more
doaj   +1 more source

The Immune Landscape of Acral Melanoma: From Basic to Clinical

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Acral melanoma (AM) is an aggressive melanoma subtype with poor prognosis and limited response to immune checkpoint inhibitors (ICIs). Despite increasing research efforts, the mechanisms underlying therapeutic resistance remain incompletely understood.
Lihong Jiang, Zhaotian Zhang
wiley   +1 more source

Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs

Mediators of Inflammation, 2014
CD73, ecto-5′-nucleotidase, is the key enzyme catalyzing the conversion of extracellular AMP to adenosine that controls vascular permeability and immunosuppression.
Gennady G. Yegutkin, Kaisa Auvinen, Marika Karikoski, Pia Rantakari, Heidi Gerke, Kati Elima, Mikael Maksimow, Ileana B. Quintero, Pirkko Vihko, Marko Salmi, Sirpa Jalkanen   +10 more
doaj   +1 more source