Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases [PDF]
Frontiers in Physiology, 2022 Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell ...
Brian Perrino +2 more
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Effects of physical exercise on the functionality of human nucleotidases: A systematic review [PDF]
Physiological Reports, 2022 Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear.
Battastini Am +2 more
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Streptococcus suis 5’-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model [PDF]
VirulenceStreptococcus suis (S. suis) is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5’-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell
Houhui Song +2 more
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Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner [PDF]
Metabolites, 2022 Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz +4 more
doaj +2 more sources
Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors [PDF]
OncoImmunologyThe adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO.
Chang Sook Hong +4 more
doaj +2 more sources
Journal of Bacteriology, 1963 Kohn , J. (Queen Mary's Hospital, London, England) and J. L. Reis . Bacterial nucleotidases. J. Bacteriol. 86: 713–716. 1963.—The 3- and 5- nucleotidase activity in various bacterial species was investigated.
J, KOHN, J L, REIS
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p1/s1, a 3'-nucleotidase/nuclease, allows Leishmania major to circumvent host innate immune response mechanisms. [PDF]
PLoS Pathogens3'-nucleotidases/nucleases, distinct class I nucleases of protozoan parasites, play a pivotal role in extracellular purine salvage. As Leishmania are purine auxotrophs and lack de novo synthesis, ectoenzymes facilitating nucleotide and nucleic acid ...
Stella M Schmelzle +11 more
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Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation [PDF]
mBioThe fission yeast PHO regulon genes pho1, pho84, and tgp1—encoding a cell surface-associated acid phosphatase (Pho1), a plasma membrane inorganic phosphate transporter (Pho84), and a plasma membrane glycerophosphocholine transporter (Tgp1)—are strongly ...
Aleksei Innokentev +4 more
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Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification [PDF]
Biomedicines, 2023 Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen +4 more
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Mammalian 5′-Nucleotidases [PDF]
Journal of Biological Chemistry, 2003 Vera Bianchi, Józef Spychala
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