Effects of physical exercise on the functionality of human nucleotidases: A systematic review [PDF]
Physiological Reports, 2022 Nucleotidases contribute to the regulation of inflammation, coagulation, and cardiovascular activity. Exercise promotes biological adaptations, but its effects on nucleotidase activities and expression are unclear.
Cesar Eduardo Jacintho Moritz +2 more
exaly +3 more sources
Streptococcus suis 5’-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model [PDF]
VirulenceStreptococcus suis (S. suis) is an important swine bacterial pathogen and causes human infections, leading to a wide range of diseases. However, the role of 5’-nucleotidases in its virulence remains to be fully elucidated. Herein, we identified four cell
Houhui Song, ChangYong Cheng
exaly +4 more sources
Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner [PDF]
Metabolites, 2022 Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz +4 more
doaj +2 more sources
Mechanosensitive Hydrolysis of ATP and ADP in Lamina Propria of the Murine Bladder by Membrane-Bound and Soluble Nucleotidases [PDF]
Frontiers in Physiology, 2022 Prior studies suggest that urothelium-released adenosine 5′-triphosphate (ATP) has a prominent role in bladder mechanotransduction. Urothelial ATP regulates the micturition cycle through activation of purinergic receptors that are expressed in many cell ...
Mafalda S. L. Aresta Branco +4 more
doaj +2 more sources
Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors [PDF]
OncoImmunologyThe adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO.
Chang Sook Hong +4 more
doaj +2 more sources
Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis [PDF]
Mediators of Inflammation, 2014 Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic
Laura Texidó +9 more
doaj +2 more sources
High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors [PDF]
Mediators of Inflammation, 2014 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Elisabet Aliagas +5 more
doaj +2 more sources
Journal of Bacteriology, 1963 Kohn , J. (Queen Mary's Hospital, London, England) and J. L. Reis . Bacterial nucleotidases. J. Bacteriol. 86: 713–716. 1963.—The 3- and 5- nucleotidase activity in various bacterial species was investigated.
J, KOHN, J L, REIS
exaly +3 more sources
E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi).
Lisvane Paes-Vieira +3 more
doaj +2 more sources
Efn1 and Efn2 are extracellular 5'-nucleotidases induced during the fission yeast response to phosphate starvation [PDF]
mBioThe fission yeast PHO regulon genes pho1, pho84, and tgp1—encoding a cell surface-associated acid phosphatase (Pho1), a plasma membrane inorganic phosphate transporter (Pho84), and a plasma membrane glycerophosphocholine transporter (Tgp1)—are strongly ...
Aleksei Innokentev +4 more
doaj +2 more sources