Relative gene expression of nucleotidases in FRT epithelial cells. [PDF]
, 2013 Data is shown as the ratio of the nucleotidase (NT) gene expression to the expression of β-actin. Purified cultures of (A) FT n = 3, (B) EM n = 8, (C) CX n = 8 and (D) ECX n = 10 epithelial cells were analyzed for changes in nucleotidase gene expression ...
Jack E. Bodwell (437165) +7 more
core +1 more source
Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors [PDF]
Royal Society Open Science, 2018 Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling.
Sidra Hassan +7 more
doaj +1 more source
The pharmacological role of nucleotidases in snake venoms [PDF]
, 2010 Several hydrolytic enzymes of snake venom have evolved to interfere in various physiological processes, which are well defined. However, hydrolytic enzymes such as nucleotidases (5′nucleotidase, ATPase, and ADPase) are less studied and their ...
Dhananjaya, B. L., D'Souza, C. J. M.
core +1 more source
Cell wall‐anchored 5′‐nucleotidases in Gram‐positive cocci [PDF]
, 2020 5'-nucleotidases (5'-NTs) are enzymes that catalyze the hydrolysis of nucleoside monophosphates to produce nucleosides and phosphate. Since the identification of adenosine synthase A (AdsA) in Staphylococcus aureus in 2009, several other 5'-NTs have been
Jacelyn M. S. Loh +5 more
core +1 more source
Frontiers in Immunology, 2019 Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses.
Alberto L. Horenstein +6 more
doaj +1 more source
Combined deletion of cytosolic 5'-nucleotidases IA and II lowers glycemia by improving skeletal muscle insulin action and lowering hepatic glucose production. [PDF]
J Biol ChemObesity and type 2 diabetes (T2D)-linked hyperglycemia, along with their associated complications, have reached pandemic proportions, constituting a major public health issue.
Jacobs R +6 more
europepmc +2 more sources
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas, Nicholas Dale
core +1 more source
Annals of Neurology, EarlyView.Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello +20 more
wiley +1 more source
Conserved catalytic sequence motifs of the intracellular human 5′-nucleotidases and cN-IIIB. [PDF]
, 2014 Sequence conservation of catalytic motifs of 5′-nucleotidases completed by the new member cN-IIIB. The respective motifs of HscN-IIIB and DmcN-IIIB have been deduced from the crystal structure and sequence analyses.
Piotr Neumann (361820) +4 more
core +1 more source
Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP.
PLoS ONE, 2014 5'-nucleotidases catalyze the hydrolytic dephosphorylation of nucleoside monophosphates. As catabolic enzymes they contribute significantly to the regulation of cellular nucleotide levels; misregulation of nucleotide metabolism and nucleotidase ...
Thomas Monecke +4 more
doaj +1 more source