Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases [PDF]
Frontiers in Immunology, 2018 Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression.
Allan Dantas Dos Santos +2 more
exaly +7 more sources
Cellular function and molecular structure of ecto-nucleotidases [PDF]
Purinergic Signalling, 2012 Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate extracellular nucleosides for cellular reuptake and salvage via nucleoside transporters of the plasma membrane. The extracellular adenosine formed acts as an
Herbert Zimmermann +2 more
exaly +5 more sources
Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis [PDF]
Mediators of Inflammation, 2014 Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic pain, and infertility being the main characteristics.
Laura Texidó +9 more
doaj +6 more sources
High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors [PDF]
Mediators of Inflammation, 2014 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects. The study of the mechanisms leading to adenosine formation at the tumor interstitium are therefore of great interest in oncology. The dominant pathway generating extracellular adenosine
Elisabet Aliagas +5 more
doaj +6 more sources
Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions. [PDF]
PLoS Computational Biology, 2020 Nucleotides comprise small molecules that perform critical signaling roles in biological systems. Adenosine-based nucleotides, including adenosine tri-, di-, and mono-phosphate, are controlled through their rapid degradation by diphosphohydrolases and ...
Hadi Rahmaninejad +4 more
doaj +5 more sources
Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma [PDF]
Purinergic Signalling, 2014 Phosphohydrolysis of extracellular ATP and ADP is an essential step in purinergic signaling that regulates key pathophysiological processes, such as those linked to inflammation. Classically, this reaction has been known to occur in the pericellular milieu catalyzed by membrane bound cellular ecto-nucleotidases, which can be released in the form of ...
Simon C Robson +2 more
exaly +5 more sources
Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. [PDF]
Purinergic Signal, 2013 Extracellular ATP and its hydrolysis product, adenosine, acting through specific receptors collectively named purinergic receptors, regulate female fertility by influencing the endometrial fluid microenvironment. There are four major groups of ecto-nucleotidases that control the levels of extracellular ATP and adenosine and thus their availability at ...
Aliagas E +8 more
europepmc +4 more sources
The Role of the Ecto-Nucleotidases CD73 and CD39 in Chemo- and Immunotherapy. [PDF]
Cancers (Basel)Immunotherapy, particularly effective in tumors with a high mutational burden, is very often administered in combination with chemotherapy. Several tumor types with a high mutational rate include melanoma and non-small cell lung cancer (NSCLC), which are particularly sensitive to immunotherapy.
Mucha PT +7 more
europepmc +2 more sources
Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors [PDF]
OncoImmunologyThe adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO.
Chang Sook Hong +4 more
doaj +2 more sources
p1/s1, a 3'-nucleotidase/nuclease, allows Leishmania major to circumvent host innate immune response mechanisms. [PDF]
PLoS Pathogens3'-nucleotidases/nucleases, distinct class I nucleases of protozoan parasites, play a pivotal role in extracellular purine salvage. As Leishmania are purine auxotrophs and lack de novo synthesis, ectoenzymes facilitating nucleotide and nucleic acid ...
Stella M Schmelzle +11 more
doaj +2 more sources