Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis [PDF]
Mediators of Inflammation, 2014 Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic
Laura Texidó +9 more
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High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors [PDF]
Mediators of Inflammation, 2014 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Elisabet Aliagas +5 more
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Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases [PDF]
Frontiers in Immunology, 2018 Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression.
Márcio Bezerra Santos +2 more
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Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions. [PDF]
PLoS Computational Biology, 2020 Nucleotides comprise small molecules that perform critical signaling roles in biological systems. Adenosine-based nucleotides, including adenosine tri-, di-, and mono-phosphate, are controlled through their rapid degradation by diphosphohydrolases and ...
Hadi Rahmaninejad +4 more
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Cellular function and molecular structure of ecto-nucleotidases [PDF]
Purinergic Signalling, 2012 Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate extracellular nucleosides for cellular reuptake and salvage via nucleoside transporters of the plasma membrane. The extracellular adenosine formed acts as an
Herbert Zimmermann +2 more
exaly +5 more sources
Assessment of adenosinergic activity of small extracellular vesicles in plasma of cancer patients and healthy donors [PDF]
OncoImmunologyThe adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO.
Chang Sook Hong +4 more
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E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Belonging to the GDA1/CD39 protein superfamily, nucleoside triphosphate diphosphohydrolases (NTPDases) catalyze the hydrolysis of ATP and ADP to the monophosphate form (AMP) and inorganic phosphate (Pi).
Lisvane Paes-Vieira +3 more
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Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification [PDF]
Biomedicines, 2023 Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen +4 more
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Extracellular cAMP-Adenosine Pathway Signaling: A Potential Therapeutic Target in Chronic Inflammatory Airway Diseases [PDF]
Frontiers in Immunology, 2022 Adenosine is a purine nucleoside that, via activation of distinct G protein-coupled receptors, modulates inflammation and immune responses. Under pathological conditions and in response to inflammatory stimuli, extracellular ATP is released from damaged ...
Enio Setsuo Arakaki Pacini +3 more
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Purinergic signalling: past, present and future [PDF]
Brazilian Journal of Medical and Biological Research, 2009 The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock
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