Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma [PDF]
Purinergic Signalling, 2014 Phosphohydrolysis of extracellular ATP and ADP is an essential step in purinergic signaling that regulates key pathophysiological processes, such as those linked to inflammation. Classically, this reaction has been known to occur in the pericellular milieu catalyzed by membrane bound cellular ecto-nucleotidases, which can be released in the form of ...
Zhenghui Gordon Jiang +2 more
exaly +5 more sources
Editorial: Adenosine metabolism in cardiovascular and smooth muscle [PDF]
Frontiers in PharmacologyBarbara Kutryb-Zając +4 more
doaj +2 more sources
Ecto-nucleotidases distribution in human cyclic and postmenopausic endometrium. [PDF]
Purinergic Signal, 2013 Extracellular ATP and its hydrolysis product, adenosine, acting through specific receptors collectively named purinergic receptors, regulate female fertility by influencing the endometrial fluid microenvironment. There are four major groups of ecto-nucleotidases that control the levels of extracellular ATP and adenosine and thus their availability at ...
Aliagas E +8 more
europepmc +4 more sources
The Role of the Ecto-Nucleotidases CD73 and CD39 in Chemo- and Immunotherapy. [PDF]
Cancers (Basel)Immunotherapy, particularly effective in tumors with a high mutational burden, is very often administered in combination with chemotherapy. Several tumor types with a high mutational rate include melanoma and non-small cell lung cancer (NSCLC), which are particularly sensitive to immunotherapy.
Mucha PT +7 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Leishmania (Viannia) braziliensis has been associated with a broad range of clinical manifestations ranging from a simple cutaneous ulcer to destructive mucosal lesions.
Pauline M Leite +12 more
doaj +1 more source
Influence of Ecto-nucleoside triphosphate diphosphohydrolase activity on Trypanosoma cruzi infectivity and virulence. [PDF]
PLoS Neglected Tropical Diseases, 2009 BACKGROUND: The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when most patients are diagnosed.
Ramon F Santos +8 more
doaj +1 more source
Ecto-nucleotidase activities in the fat body ofRhodnius prolixus [PDF]
Archives of Insect Biochemistry and Physiology, 2005 In this study, we describe the ability of intact fat body of an insect, Rhodnius prolixus, to hydrolyze extracellular ATP. In these fat bodies, the ATP hydrolysis was low in the absence of any divalent metal, and was stimulated by MgCl(2). Both activities (in the absence or presence of MgCl(2)) were linear with time for at least 30 min.
Petter F, Entringer +2 more
openaire +2 more sources
Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors [PDF]
Royal Society Open Science, 2018 Ecto-5′-nucleotidase (e5′NT), a membrane-bound enzyme and an essential member of ecto-nucleotidases which regulates extracellular purinergic signalling.
Sidra Hassan +7 more
doaj +1 more source
Neurobiology of Disease, 2021 Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR).
Elisabete Augusto +11 more
doaj +1 more source