The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance [PDF]
, 2011 Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized.
Robson, Simon Christopher +2 more
core +1 more source
Rat pancreas secretes particulate ecto-nucleotidase CD39
The Journal of Physiology, 2003 In exocrine pancreas, acini release ATP and the excurrent ducts express several types of purinergic P2 receptors. Thereby, ATP, or its hydrolytic products, might play a role as a paracrine regulator between acini and ducts. The aim of the present study was to elucidate whether this acinar-ductal signalling is regulated by nucleotidase(s), and to ...
Sørensen, Christiane Elisabeth +4 more
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ATP as a Multi-target Danger Signal in the Brain
Frontiers in Neuroscience, 2015 ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia ...
Ricardo J Rodrigues +4 more
doaj +1 more source
Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]
, 2008 Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Wall, Mark J., Dale, Nicholas
core +1 more source
Catabolism of Ap4A and Ap5A by rat brain synaptosomes
Brazilian Journal of Medical and Biological Research, 1998 Adenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) and adenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) are stored in and released from rat brain synaptic terminals.
T. Emanuelli +3 more
doaj +1 more source
Frontiers in Immunology, 2020 Despite the relevant antitumor efficacy of immunotherapy in advanced non-small cell lung cancer (NSCLC), the results in patients whose cancer harbors activating epidermal growth factor receptor (EGFR) mutations are disappointing.
Anna Passarelli +3 more
doaj +1 more source
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway [PDF]
, 2015 G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their cellular distribution and ...
Duarte, Thiago +2 more
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Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. [PDF]
PLoS ONE, 2013 Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV ...
Nabanita Biswas +6 more
doaj +1 more source
ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion
Physiological Reports, 2022 ATP has been previously identified as an autocrine signaling factor that is co‐released with insulin to modulate and propagate β‐cell activity within islets of Langerhans.
Sebastian Hauke +4 more
doaj +1 more source
Cholesterol-dependent Lipid Assemblies Regulate the Activity of the Ecto-nucleotidase CD39 [PDF]
Journal of Biological Chemistry, 2005 CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1; E-NTPDase1) is a plasma membrane ecto-enzyme that regulates purinergic receptor signaling by controlling the levels of extracellular nucleotides. In blood vessels this enzyme exhibits a thromboregulatory role through the control of platelet aggregation.
Papanikolaou, A. +8 more
openaire +5 more sources