Results 31 to 40 of about 1,358 (148)
Cholesterol-dependent Lipid Assemblies Regulate the Activity of the Ecto-nucleotidase CD39 [PDF]
Journal of Biological Chemistry, 2005 CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1; E-NTPDase1) is a plasma membrane ecto-enzyme that regulates purinergic receptor signaling by controlling the levels of extracellular nucleotides. In blood vessels this enzyme exhibits a thromboregulatory role through the control of platelet aggregation.
Papanikolaou, A. +8 more
openaire +5 more sources
Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. [PDF]
PLoS ONE, 2013 Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV ...
Nabanita Biswas +6 more
doaj +1 more source
ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion
Physiological Reports, 2022 ATP has been previously identified as an autocrine signaling factor that is co‐released with insulin to modulate and propagate β‐cell activity within islets of Langerhans.
Sebastian Hauke +4 more
doaj +1 more source
Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161 [PDF]
Purinergic Signalling, 2015 CD39/ENTPD1 is a prototypic member of the ectonucleoside triphosphate diphosphohydrolase (ENTPDase) family on cell surface. CD39 has been reported to be a marker of regulatory immune cells and catalyzes extracellular hydrolysis of nucleotides to generate AMP and, in tandem with CD73, adenosine.
Aiping, Bai, Simon, Robson
openaire +2 more sources
Journal of Pharmacological Sciences, 2004 The studies aiming to understand the function of purinoceptors in the central nervous system (CNS), which has been explored mostly in isolated and cultured cell systems, are now at the stage of identifying their physiological and pathophysiological ...
Fusao Kato +4 more
doaj +1 more source
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
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The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain. [PDF]
PLoS ONE, 2017 Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in the postnatal brain. Microglia express all essential purinergic elements such as receptors, nucleoside transporters and ecto-enzymes, including CD39 ...
Marina Matyash +4 more
doaj +1 more source
Regulation of the Ecto-Nucleotidase Pathway in Rat Hippocampal Nerve Terminals [PDF]
Neurochemical Research, 2001 Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals.
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Increased Ap4A levels and ecto-nucleotidase activity in glaucomatous mice retina [PDF]
Purinergic Signalling, 2018 The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of degradation machinery through ecto-nucleotidase activity are participating in the modulation of the suitable ...
Pérez de Lara, María Jesús +5 more
openaire +3 more sources
Medicine in Drug Discovery, 2019 This review covers a broad spectrum of issues related to extracellular adenine compounds within the cardiovascular system. Topics covered include: the cellular sources and detection of extracellular adenine compounds; the ecto-enzymes that mediate their ...
Gerald Soslau
doaj +1 more source