Results 21 to 30 of about 1,358 (148)

RanBPM associates with CD39 and modulates ecto-nucleotidase activity [PDF]

Biochemical Journal, 2006
CD39/ecto-NTPDase 1 (nucleoside triphosphate diphosphohydrolase 1) is an ecto-nucleotidase that influences P2 receptor activation to regulate vascular and immune cell adhesion and signalling events pivotal in inflammation. Whether CD39 interacts with other membrane or cytoplasmic proteins has not been established to date.
Yan, Wu, Xiaofeng, Sun, Elzbieta, Kaczmarek, Karen M, Dwyer, Elisabetta, Bianchi, Anny, Usheva, Simon C, Robson   +6 more
openaire   +2 more sources

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Adenosine Receptor Activation by ATP Through Rapid and Localized Generation of Adenosine by Ecto-nucleotidases

Journal of Pharmacological Sciences, 2004
Extracellular ATP is now recognized as a neurotransmitter or neuromodilator in the nervous system, producing diverse physiological effects by activating multiple P2 receptors.
Isao Matsuoka, Satoko Ohkubo
doaj   +1 more source

Ectonucleotidases in Acute and Chronic Inflammation

Frontiers in Pharmacology, 2021
Ectonucleotidases are extracellular enzymes with a pivotal role in inflammation that hydrolyse extracellular purine and pyrimidine nucleotides, e.g., ATP, UTP, ADP, UDP, AMP and NAD+. Ectonucleotidases, expressed by virtually all cell types, immune cells
Anna Lisa Giuliani, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

Extracellular ATP: A Feasible Target for Cancer Therapy

Cells, 2020
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors ...
Valentina Vultaggio-Poma, Alba Clara Sarti, Francesco Di Virgilio   +2 more
doaj   +1 more source

Some aspects of purinergic signaling in the ventricular system of porcine brain

Acta Veterinaria Scandinavica, 2011
Background Numerous signaling pathways function in the brain ventricular system, including the most important - GABAergic, glutaminergic and dopaminergic signaling. Purinergic signalization system - comprising nucleotide receptors, nucleotidases, ATP and
Komoszyński Michał, Smoliński Dariusz, Jabłoński Artur, Roszek Katarzyna, Czarnecka Joanna   +4 more
doaj   +1 more source

Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.

PLoS ONE, 2016
ATP induces pain via activation of purinergic receptors in nociceptive sensory nerves. ATP signaling is terminated by ATP hydrolysis mediated by cell surface-localized ecto-nucleotidases.
Lihua Ma, Thu Trinh, Yanfang Ren, Robert T Dirksen, Xiuxin Liu   +4 more
doaj   +1 more source

Rat pancreas secretes particulate ecto-nucleotidase CD39

The Journal of Physiology, 2003
In exocrine pancreas, acini release ATP and the excurrent ducts express several types of purinergic P2 receptors. Thereby, ATP, or its hydrolytic products, might play a role as a paracrine regulator between acini and ducts. The aim of the present study was to elucidate whether this acinar-ductal signalling is regulated by nucleotidase(s), and to ...
Sørensen, Christiane Elisabeth, Amstrup, Jan, Rasmussen, Hans N, Ankorina-Stark, Ieva, Novak, Ivana   +4 more
openaire   +4 more sources

ATP as a Multi-target Danger Signal in the Brain

Frontiers in Neuroscience, 2015
ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia ...
Ricardo J Rodrigues, Angelo R Tomé, Angelo R Tomé, Rodrigo A Cunha, Rodrigo A Cunha   +4 more
doaj   +1 more source

Catabolism of Ap4A and Ap5A by rat brain synaptosomes

Brazilian Journal of Medical and Biological Research, 1998
Adenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) and adenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) are stored in and released from rat brain synaptic terminals.
T. Emanuelli, C.D. Bonan, J.J.F. Sarkis, A.M.O. Battastini   +3 more
doaj   +1 more source

Targeting Immunometabolism Mediated by CD73 Pathway in EGFR-Mutated Non-small Cell Lung Cancer: A New Hope for Overcoming Immune Resistance

Frontiers in Immunology, 2020
Despite the relevant antitumor efficacy of immunotherapy in advanced non-small cell lung cancer (NSCLC), the results in patients whose cancer harbors activating epidermal growth factor receptor (EGFR) mutations are disappointing.
Anna Passarelli, Michele Aieta, Alessandro Sgambato, Cesare Gridelli   +3 more
doaj   +1 more source