Results 41 to 50 of about 2,507 (197)
Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]
, 2017 Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R +5 more
core +2 more sources
Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161 [PDF]
Purinergic Signalling, 2015 CD39/ENTPD1 is a prototypic member of the ectonucleoside triphosphate diphosphohydrolase (ENTPDase) family on cell surface. CD39 has been reported to be a marker of regulatory immune cells and catalyzes extracellular hydrolysis of nucleotides to generate AMP and, in tandem with CD73, adenosine.
Aiping, Bai, Simon, Robson
openaire +2 more sources
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann +23 more
wiley +2 more sources
Journal of Pharmacological Sciences, 2004 The studies aiming to understand the function of purinoceptors in the central nervous system (CNS), which has been explored mostly in isolated and cultured cell systems, are now at the stage of identifying their physiological and pathophysiological ...
Fusao Kato +4 more
doaj +1 more source
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
doaj +1 more source
The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain. [PDF]
PLoS ONE, 2017 Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in the postnatal brain. Microglia express all essential purinergic elements such as receptors, nucleoside transporters and ecto-enzymes, including CD39 ...
Marina Matyash +4 more
doaj +1 more source
Regulation of the Ecto-Nucleotidase Pathway in Rat Hippocampal Nerve Terminals [PDF]
Neurochemical Research, 2001 Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals.
openaire +3 more sources
Intracortical injection of endothelin-1 induces cortical infarcts in mice: effect of neuronal expression of an adenosine transporter [PDF]
, 2012 Background Activation of adenosine A1 receptors has neuroprotective effects in animal stroke models. Adenosine levels are regulated by nucleoside transporters.
Benedict C Albensi +5 more
core +2 more sources
Increased Ap4A levels and ecto-nucleotidase activity in glaucomatous mice retina [PDF]
Purinergic Signalling, 2018 The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of degradation machinery through ecto-nucleotidase activity are participating in the modulation of the suitable ...
Pérez de Lara, María Jesús +5 more
openaire +3 more sources
Medicine in Drug Discovery, 2019 This review covers a broad spectrum of issues related to extracellular adenine compounds within the cardiovascular system. Topics covered include: the cellular sources and detection of extracellular adenine compounds; the ecto-enzymes that mediate their ...
Gerald Soslau
doaj +1 more source