Results 61 to 70 of about 2,507 (197)

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand [PDF]

, 2014
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands.
Barrett, Matthew O, Brown, Kyle A, Harden, T Kendall, Karalic, Izet, Risseeuw, Martijn, Song, Lijun, Van Calenbergh, Serge   +6 more
core   +4 more sources

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Use of methanol as cryoprotectant and its effect on sox genes and proteins in chilled zebrafish embryos [PDF]

, 2015
Methanol is a widely used cryoprotectant (CPA) in cryopreservation of fish embryos, however little is known about its effect at the molecular level. This study investigated the effect of methanol on sox gene and protein expression in zebrafish embryos ...
Ahammad, Andrews, Arav, Avilion, Crémazy, Dee, Degitz, Desai, Dinnyés, Dong, Drobnis, Eells, Emma Spikings, Ferri, Fuller, Graham, Guan, Hagedorn, Kimmel, Kishi, Kopeika, Kunjan Desai, Lahnsteiner, Lee, Lin, Liu, Mattick, Mellerick, Millimaki, Nagashima, Nageshan, Nie, Okuda, Overton, Pfaffl, Pillai, Plachinta, Rico, Shi, Smith, Tan, Tiantian Zhang, Tsai, Valdez, Vriz, Zampolla, Zeron, Zhang, Zhang, Zhang, Zhang, Zhang   +51 more
core   +3 more sources

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Chouker, A., Dugas, Martin, Heizmann, O., Martignoni, A., Messmer, K., Peter, K., Rau, H. G., Schauer, R. J., Thiel, M., Volk, A.   +9 more
core   +1 more source

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the “adenosine hypothesis” [PDF]

Purinergic Signalling, 2013
Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D2 receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constitutes a main source of extracellular adenosine.
Elisabet, Aliagas, Izaskun, Villar-Menéndez, Jean, Sévigny, Mercedes, Roca, Miriam, Romeu, Isidre, Ferrer, Mireia, Martín-Satué, Marta, Barrachina   +7 more
openaire   +2 more sources

The ecto‐nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor‐dependent vasorelaxation [PDF]

British Journal of Pharmacology, 2010
Background and purpose: Extracellular nucleotides produce vasodilatation through endothelial P2 receptor activation. As these autacoids are actively metabolized by the ecto‐nucleotidase nucleoside triphosphate diphosphohydrolase‐1 (NTPDase1), we studied the effects of this cell surface enzyme on nucleotide‐dependent vasodilatation.Experimental approach:
Gilles, Kauffenstein, Cristina Ribas, Fürstenau, Pedro, D'Orléans-Juste, Jean, Sévigny   +3 more
openaire   +2 more sources

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices [PDF]

, 2003
Electrophysiological recordings were used to investigate the effects of ATP analogues on [theta]-burst-induced long-term potentiation (LTP) in rat hippocampal slices.
Almeida, T., Cunha, R. A., Mendonça, A. de, Ribeiro, J. A., Rodrigues, R. J.   +4 more
core   +1 more source

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo, Huan Chen, Ali Wu, Weipu Mao, Sagar Barge, Seth L. Alper, Simon C. Robson, Weiqun Yu   +7 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source