Results 61 to 70 of about 1,358 (148)

Development of aortic endothelial cells to express CD37 and CD73 isolated from alpha 1,3-galactosyltransferase knock-out and MCP expressing pig

Journal of Animal Reproduction and Biotechnology, 2018
Acute vascular rejection has been known as a main barrier occurring in a xenograted tissue of alpha 1,3-galactosyltransferase knock-out (GalT KO) pig into a non-human primate (NHP). Adenosine which is a final metabolite following sequential hydrolysis of
Jin-Gu No, Sung-June Byun, Hyeon Yang, Sun A Ock, Jae-Seok Woo, Hwi-Cheul Lee, In-sul Hwang, Ji-Youn Kim, Sang Hyoun Park, Joo Young Lee, Keon Bong Oh   +10 more
doaj   +1 more source

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model

BMC Cancer, 2006
Background ATP is an important signalling molecule in the peripheral and central nervous system. Both glioma growth and tumor resection induces cell death, thus liberating nucleotides to the extracellular medium. Nucleotides are hydrolyzed very slowly by
Meurer Luise, Wink Márcia R, Wofchuk Suzana, Stella Joseli, Gamermann Patrícia, Oliveira Diogo L, Morrone Fernanda B, Edelweiss Maria, Lenz Guido, Battastini Ana   +9 more
doaj   +1 more source

Dysregulation of CD39/Ectonucleoside Triphosphate Diphosphohydrolase 1 Causes Urinary Bladder Dysfunction with Abnormal Smooth Muscle Contractility

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Abnormal extracellular ATP levels cause lower urinary tract symptoms (LUTS). Here, we demonstrate that overexpression of ENTPD1 (CD39TG)—an ATP/ADP converting enzyme—reduces voiding frequency while increasing void volume. Conversely, ENTPD1 deficiency results in frequent, small‐volume voiding.
Zhaobo Luo, Huan Chen, Ali Wu, Weipu Mao, Sagar Barge, Seth L. Alper, Simon C. Robson, Weiqun Yu   +7 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes.

Acta Biochimica Polonica, 2014
It is widely accepted that purinergic signaling is involved in the regulation of functions of all known tissues and organs. Extracellular purines activate two classes of receptors, P1-adenosine receptors and P2-nucleotide receptors, in a concentration-dependent manner.
Marek, Cieślak, Katarzyna, Roszek
openaire   +3 more sources

Adenosine Metabolism Pathway Alterations in Frontal Cortical Neurons in Schizophrenia

Cells
Schizophrenia is a neuropsychiatric illness characterized by altered neurotransmission, in which adenosine, a modulator of glutamate and dopamine, plays a critical role that is relatively unexplored in the human brain.
Smita Sahay, Emily A. Devine, Christina F.-A. Vargas, Robert E. McCullumsmith, Sinead M. O’Donovan   +4 more
doaj   +1 more source

Ecto-nucleotidases as potential biomarkers for diagnosis of endometriosis

, 2017
Introduction: Endometriosis is an inflammatory disorder characterized by the growth of endometrial tissue in extrauterine locations. Ovarian endometriomas are a common form of endometriosis. Late diagnosis is the main problem in the pathology; thus, it is important to identify clinical biomarkers.
Trapero, Carla, Vidal-Bel, August, Jover, Lluís, Fernández Montolí, Ma. Eulalia, García Tejedor, María Amparo, Ponce i Sebastià, Jordi, Tresserra, Francesc, Barri, Pere, Coroleu, Buenaventura, Martín Satué, Mireia   +9 more
openaire   +1 more source

Role of ecto-nucleotidases in human endometrial pathologies

, 2017
Abstract from the VII International Congress of Histology and Tissue Engineering - XIX Congress of the Spanish Society of Histology and Tissue Engineering - IV Iberoamerican Congress of Histology.
Martín Satué, Mireia, Vidal-Bel, August, Rodríguez-Martínez, Aitor, Trapero, Carla, Villamonte-Román, María, Fernández Montolí, Ma. Eulalia, Piulats, Josep M., Coroleu, Buenaventura, Ponce i Sebastià, Jordi, Matias-Guiu, Xavier, 1958-   +9 more
openaire   +1 more source

NTPDase1-ATP-P2Y2Rs axis in the sciatic nerve contributes to acupuncture at “Zusanli” (ST36)-induced analgesia in ankle arthritis rats

Brain Research Bulletin
Background: The efficacy of acupuncture at Zusanli (ST36) in alleviating lower-limb pain is widely acknowledged in clinical practice, while its underlying mechanism remains incompletely elucidated.
Jing-Wen Xu, Si-Qi Tang, Jie Lin, Yu-Jia Li, Dan Shen, Guang-Hong Ding, Xue-Yong Shen, Li-Na Wang   +7 more
doaj   +1 more source