Results 81 to 90 of about 2,507 (197)

In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model

BMC Cancer, 2006
Background ATP is an important signalling molecule in the peripheral and central nervous system. Both glioma growth and tumor resection induces cell death, thus liberating nucleotides to the extracellular medium. Nucleotides are hydrolyzed very slowly by
Meurer Luise, Wink Márcia R, Wofchuk Suzana, Stella Joseli, Gamermann Patrícia, Oliveira Diogo L, Morrone Fernanda B, Edelweiss Maria, Lenz Guido, Battastini Ana   +9 more
doaj   +1 more source

Reply [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108083/1/hep26952 ...
Omary, M. Bishr, Snider, Natasha T.
core   +1 more source

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, Volume 26, Issue 2-3, Page 81-94, February 2026.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

Soluble Mediators Regulating Immunity in Early Life [PDF]

, 2014
Soluble factors in blood plasma have a substantial impact on both the innate and adaptive immune responses. The complement system, antibodies, and anti-microbial proteins and peptides can directly interact with potential pathogens, protecting against ...
Levy, Ofer, Pettengill, Matthew Aaron, van Haren, Simon Daniël   +2 more
core   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Applications of polyoxometalates in medicine and their putative mechanisms of action [PDF]

, 2015
Relatório de Estágio de Licenciatura, Bioquímica, Faculdade de Ciências e Tecnologias da Universidade do Algarve, 2015Polyoxometalates (POMs) are inorganic metal-oxide assemblies presenting a wide range of possible structure, size and metal-combination,
Authier, Tatiana
core  

P2X receptor: Death or life? [PDF]

, 2005
The P2X7 plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation.
Elena Adinolfi, Cinzia Pizzirani, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Francesco Di Virgilio, Davide Ferrari, A Gartland, A Solini, A Solini, BA O’Reilly, BA O’Reilly, NM Slater, W Tassell, HY Lee, AV Greig, Q Li, S Cockcroft, S Cockcroft, JL Gordon, TH Steinberg, S Greenberg, A Surprenant, W Freist, RA Worthington, RA North, RA North, TH Steinberg, F Virgilio Di, F Virgilio Di, C Virginio, D Ferrari, TM Chused, F Markwardt, P Pizzo, F Rassendren, C Virginio, T Watano, Y Hu, S Adriouch, H Stunff Le, ML Smart, BJ Gu, R Sluyter, BJ Gu, JS Wiley, M Klapperstuck, ML Smart, PE Tatham, R Coutinho-Silva, MY Kochukov, A MacKenzie, A Morelli, PA Verhoef, M Kim, M Kim, E Adinolfi, HL Wilson, LC Denlinger, CE Gargett, K Larsson Per, T Pannicke, A Colomar, KL Kimm-Brinson, SA Deuchars, B Sperlagh, JN Armstrong, M Kukley, JA Sim, S Duan, MC Jacques-Silva, M Murgia, BD Humphreys, LH Jiang, G Buell, PJ Nijweide, F Virgilio Di, P Zanovello, LM Zheng, BD Humphreys, D Ferrari, JM Sanz, Q Wang, H Franke, T Suzuki, MP Courageot, M Seman, F Scheuplein, A Solini, JI Elliott, P Chiozzi, A Molloy, DA Lammas, IP Fairbairn, CM Li, BM Saunders, S Falzoni, BD Humphreys, BD Humphreys, KA Hogquist, D Ferrari, D Ferrari, R Feuvre Le, M Solle, JM Labasi, OR Baricordi, OR Baricordi, V Budagian, M Bradford, FP Gendron, LK Parvathenani, LM Graves, AJ Whitmarsh, JS Wiley, JS Wiley, E Adinolfi, JS Wiley, U Thunberg, O Guipaud, J Starczynski, LY Zhang, H Nuckel, GS Sellick, AV Greig, M Slater, KA Jacobson, JM Sanz, D Ferrari, CE Gargett, PG Baraldi, PG Baraldi, PG Baraldi, AN Shemon, A Baxter, L Alcaraz, PW Szlosarek   +135 more
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Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

Cancer Medicine, Volume 15, Issue 1, January 2026.
Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang, Binle Tian, Jingyi Zhou, Di Ma, Rongze Sun, Qi Li   +5 more
wiley   +1 more source

Synthesis and Structure-Activity Relationships of Pyridoxal-6-arylazo-5'-phosphate and Phosphonate Derivatives as P2 Receptor Antagonists. [PDF]

, 1998
Novel analogs of the P2 receptor antagonist pyridoxal-5'-phosphate-6-phenylazo-2',4'-disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the ...
Boyer, José L., Burnstock, Geoffrey, Camaioni, Emidio, Harden, T. Kendall, Jacobson, Kenneth A., Ji, Xiao-Duo, Kim, Heaok, Kim, Yong-Chul, King, Brian F., Mohanram, Arvind, Rychkov, Alexei, Wildman, Scott S.P., Yoburn, Joshua, Ziganshin, Airat U.   +13 more
core   +3 more sources

Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts [PDF]

, 2019
© 2019 Published by Elsevier Inc.Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as hydroxyapatite, inthe medial layer of the arteries.
Arnett, Timothy R, Bourne, Lucie E, Davies, Bethan K, MacRae, Vicky E, Orriss, Isabel R, Patel, Jessal, Wheeler-Jones, Caroline P D   +6 more
core   +6 more sources