The Journal of Physiology, Volume 604, Issue 1, Page 626-652, 1 January 2026.Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael +4 more
wiley +1 more source
Acta Biochimica Polonica, 2014 It is widely accepted that purinergic signaling is involved in the regulation of functions of all known tissues and organs. Extracellular purines activate two classes of receptors, P1-adenosine receptors and P2-nucleotide receptors, in a concentration-dependent manner.
Marek, Cieślak, Katarzyna, Roszek
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Adenosine Metabolism Pathway Alterations in Frontal Cortical Neurons in Schizophrenia
CellsSchizophrenia is a neuropsychiatric illness characterized by altered neurotransmission, in which adenosine, a modulator of glutamate and dopamine, plays a critical role that is relatively unexplored in the human brain.
Smita Sahay +4 more
doaj +1 more source
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress [PDF]
, 2006 We previously demonstrated that insulin has a neuroprotective role against oxidative stress, a deleterious condition associated with diabetes, ischemia, and age-related neurodegenerative diseases.
Duarte, Ana I. +4 more
core +2 more sources
Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]
, 2012 Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Dale, Nicholas +3 more
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The Protective Effects of CD39 Overexpression in Multiple Low-Dose Streptozotocin–Induced Diabetes in Mice [PDF]
, 2013 Islet allograft survival limits the long-term success of islet transplantation as a potential curative therapy for type 1 diabetes. A number of factors compromise islet survival, including recurrent diabetes.
Chen, Jiang-Fan +11 more
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Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy [PDF]
, 2016 Clear signaling roles for ATP and adenosine have been established in all tissues, including the eye. The magnitude of signaling responses is governed by networks of enzymes; however, little is known about the regulatory mechanisms of purinergic signaling
Aalto, Kristiina +5 more
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Erythrocyte's aging in microgravity highlights how environmental stimuli shape metabolism and morphology [PDF]
, 2018 The determination of the function of cells in zero-gravity conditions is a subject of interest in many different research fields. Due to their metabolic unicity, the characterization of the behaviour of erythrocytes maintained in prolonged microgravity ...
Bellelli, Andrea +8 more
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From variome to phenome : pathogenesis, diagnosis and management of ectopic mineralization disorders [PDF]
, 2015 Ectopic mineralization - inappropriate biomineralization in soft tissues - is a frequent finding in physiological aging processes and several common disorders, which can be associated with significant morbidity and mortality.
De Vilder, eva, Vanakker, Olivier
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Ecto-nucleotidases as potential biomarkers for diagnosis of endometriosis
, 2017 Introduction: Endometriosis is an inflammatory disorder characterized by the growth of endometrial tissue in extrauterine locations. Ovarian endometriomas are a common form of endometriosis. Late diagnosis is the main problem in the pathology; thus, it is important to identify clinical biomarkers.
Trapero, Carla +9 more
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