Results 111 to 120 of about 1,358 (148)

Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats

Molecular and Cellular Biochemistry, 2012
In this study, we investigated the effect of 6 weeks of swimming training on the ecto-nucleotidase activities and platelet aggregation from rats that developed hypertension in response to oral administration of L-NAME. The rats were divided into four groups: control (n = 10), exercise (n = 10), L-NAME (n = 10), and exercise L-NAME (n = 10). The animals
Margarete Bagatini, Maria Rosa Chitolina Schetinger, Vera Maria Morsch   +2 more
exaly   +3 more sources

The pharmacology and kinetics of ecto-nucleotidases in the perilymphatic compartment of the guinea-pig cochlea

Hearing Research, 1998
This study investigated the characteristics of ecto-nucleotidases in tissues lining the perilymphatic cavity of the cochlea. The perilymphatic space of the isolated guinea-pig cochlea was maintained with oxygenated artificial perilymph (AP) perfused at a rate of 100 microl/min.
Srdjan Vlajkovic, Gary Housley, Peter Thorne   +2 more
exaly   +3 more sources

Ecto-Nucleotidases

2001
Herbert Zimmermann, Zimmermann H
exaly   +2 more sources

Ecto-Nucleotidases

1997
Teresa Miras-Portugal, Pedro Rotllán, Jesus Mateo   +2 more
exaly   +2 more sources

Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors

Biochemical Pharmacology, 2015
Polyoxometalates (POMs) are inorganic cluster metal complexes that possess versatile biological activities, including antibacterial, anticancer, antidiabetic, and antiviral effects. Their mechanisms of action at the molecular level are largely unknown.
Lee, S.-Y., Fiene, A., Li, W., Hank, T., Brylev, K., Fedovrov, V., Lecka, J., Haider, A., Pietzsch, H.-J., Zimmermann, H., Sévigny, J., Kortz, U., Stephan, H., Müller, C. E.   +13 more
openaire   +3 more sources

Ecto-nucleotidase pathway is altered by different treatments with fluoxetine and nortriptyline

European Journal of Pharmacology, 2008
Depression is one of the most disabling diseases and causes a significant burden to both individual and society. Selective serotonin reuptake inhibitors and tricyclic antidepressants, such as fluoxetine and nortriptyline, respectively, are commonly used in treatment for depression.
Eduardo Luiz, Pedrazza, Eduardo Pacheco, Rico, Mario Roberto, Senger, Leonardo, Pedrazza, Fernanda Francine, Zimmermann, João José Freitas, Sarkis, Maurício Reis, Bogo, Carla Denise, Bonan   +7 more
openaire   +2 more sources

Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery

Mini-Reviews in Medicinal Chemistry, 2015
Ecto-nucleotidases are nucleotide metabolizing enzymes that are divided into four different families; nucleoside triphosphate diphosphohydrolases (NTPDases), ecto-5'-nucleotidase (ecto-5'-NT), nucleotide pyrophosphatase/phosphodiesterases (NPPs), and alkaline phosphatases (APs).
openaire   +2 more sources

(ECTO)NUCLEOTIDASE KINETICS OBSERVED BY31P-NMR SPECTROSCOPY: RESOLUTION OF SIGNALS

Pharmacological Research, 1997
We used 31P-NMR to study the action of the drug ouabain, a digitalis glycoside, on the ecto-nucleotidase catalysed reaction pathway: [formula: see text] Even under conditions where it was impossible to resolve all resonances from the individual species, the rate constants for the individual steps may be evaluated by a chi 2 fit of equations describing ...
Bernardi, M., Galeazzi, G., Lamura, E., Piantelli, F., Rendell, John, Rossini, L., Rossini, P.   +6 more
openaire   +3 more sources

Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma Parasites

2013
Ecto-enzymes can be defined as membrane-bound proteins that have their active site facing the extracellular millieu. In trypanosomatids, the physiological roles of these enzymes remain to be completed elucidated; however, many important events have already been related to them, such as the survival of parasites during their complex life cycle and the ...
Anita Leocadio, Freitas-Mesquita, José Roberto, Meyer-Fernandes   +1 more
openaire   +2 more sources

Ecto‐nucleotidase activities in spinal cord of rats changes as function of age

International Journal of Developmental Neuroscience, 2003
AbstractAn increase in ADP hydrolysis was observed in spinal cord synaptosomal fractions of 2‐month‐old Wistar male rats, when compared to other ages (1, 4 and 6 months of age), while no change in ATPase activity was observed. Conversely, in female rats, whilst no change in ADPase activity was observed in the spinal cord synaptosomal fraction, ATPase ...
Iraci Lucena S, Torres, Ana Maria O, Battastini, Andréia, Buffon, Cristina Ribas, Fürstenau, Ionara, Siqueira, João J F, Sarkis, Carla, Dalmaz, Maria Beatriz C, Ferreira   +7 more
openaire   +2 more sources