Results 51 to 60 of about 2,507 (197)
Resetting intrinsic purinergic modulation of neural activity: an associative mechanism? [PDF]
, 2002 The purines, ATP and adenosine, control the rundown and termination of swimming in the Xenopus embryo. This intrinsic purinergic modulation, unavoidably present during every swimming episode, could lead to stereotyped inflexible behavior and consequently
Dale, Nicholas
core +1 more source
Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1 [PDF]
Cell Death & Differentiation, 2014 Glioblastomas are highly aggressive brain tumours and are characterised by substantial cellular heterogeneity within a single tumour. A sub-population of glioblastoma stem-like cells (GSCs) that shares properties with neural precursor cells has been described, exhibiting resistance to therapy and therefore being considered responsible for the high ...
J, Bageritz +9 more
openaire +2 more sources
Adenosinergic System Involvement in Ischemic Stroke Patients’ Lymphocytes
Cells, 2020 Adenosine modulates many physiological processes through the interaction with adenosine receptors (ARs) named as A1, A2A, A2B, and A3ARs. During ischemic stroke, adenosine mediates neuroprotective and anti-inflammatory effects through ARs activation. One
Silvia Pasquini +7 more
doaj +1 more source
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]
, 2015 Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina +7 more
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Methanol and isopropanol embryo dosage response curves for wild-type and ethanol-sensitive zebrafish [PDF]
, 2016 It is well established that ethanol has an array of negative effects on developing embryos, from craniofacial abnormalities to cognitive deficits and behavioral disorders.
Anderson, Ashley
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The Journal of Physiology, EarlyView.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source
Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
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genesis, Volume 64, Issue 3, June 2026.ABSTRACT Optimizing transient expression systems in fish embryos is crucial for rapid gene function analysis. Here, we established an efficient system in medaka (Oryzias latipes) embryos by evaluating nucleic acid type and injection site. Our results revealed that injecting the elongation factor 1αA (ef1αA) promoter‐driven plasmid into the yolk yielded
Yu Murakami +3 more
wiley +1 more source
CD73 is a major regulator of adenosinergic signalling in mouse brain.
PLoS ONE, 2013 CD73 (ecto-5'-nucleotidase) is a cell surface enzyme that regulates purinergic signalling by desphosphorylating extracellular AMP to adenosine. 5'-nucleotidases are known to be expressed in brain, but the expression of CD73 and its putative physiological
Natalia Kulesskaya +6 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 5, May 2026.Acute caffeine exposure exerts coping style‐ and sex‐dependent effects on anxiety‐like behavior in zebrafish, with reactive individuals, particularly males, showing the greatest sensitivity. The accompanying changes in adenosine receptor and adenosine deaminase expression demonstrate a possible molecular mechanism underlying these behavioral ...
Sydney E. Klucas, Ryan Y. Wong
wiley +1 more source