Results 51 to 60 of about 1,358 (148)

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu, Usri H. Ibrahim, Irene Mackraj, Carola Niesler   +3 more
wiley   +1 more source

Reduced striatal ecto-nucleotidase activity in schizophrenia patients supports the “adenosine hypothesis” [PDF]

Purinergic Signalling, 2013
Schizophrenia (SZ) is a major chronic neuropsychiatric disorder characterized by a hyperdopaminergic state. The hypoadenosinergic hypothesis proposes that reduced extracellular adenosine levels contribute to dopamine D2 receptor hyperactivity. ATP, through the action of ecto-nucleotidases, constitutes a main source of extracellular adenosine.
Elisabet, Aliagas, Izaskun, Villar-Menéndez, Jean, Sévigny, Mercedes, Roca, Miriam, Romeu, Isidre, Ferrer, Mireia, Martín-Satué, Marta, Barrachina   +7 more
openaire   +2 more sources

Machine Learning for Raman Spectroscopy Glioblastoma Classification

Journal of Chemometrics, Volume 40, Issue 6, June 2026.
ABSTRACT This study presents a comprehensive evaluation of various computational models for glioblastoma cell classification using Raman spectroscopy data. We compare traditional machine learning methods such as support vector machines, boosting and random forests with more modern methods including convolutional neural networks, vision transformers and
Brendan McCane, Irsyaad Rijwan, Sara J. Fraser‐Miller, Silke Neumann, Donata Maciaczyk, Jaroslaw Maciaczyk, Keith Gordon   +6 more
wiley   +1 more source

Effect of C5a Receptor Antagonist on the Osteogenic Differentiation of Dental Pulp Stem Cells

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objective Complement component 5a (C5a) binding to its receptor (C5aR) can mediate pro‐inflammatory immune responses, which impairs osteogenic differentiation of dental pulp stem cells (DPSCs). The present study aimed to evaluate the regulatory effect of C5aR antagonist (W54011) on the osteogenic differentiation of DPSCs in an in vitro ...
Xiaohan Tan, Junlong Hu, Junhui Li, Zhuangying Chen, Xin Shi, Jie Liu, Mingyue Liu, Weiping Hu   +7 more
wiley   +1 more source

The ecto‐nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor‐dependent vasorelaxation [PDF]

British Journal of Pharmacology, 2010
Background and purpose: Extracellular nucleotides produce vasodilatation through endothelial P2 receptor activation. As these autacoids are actively metabolized by the ecto‐nucleotidase nucleoside triphosphate diphosphohydrolase‐1 (NTPDase1), we studied the effects of this cell surface enzyme on nucleotide‐dependent vasodilatation.Experimental approach:
Gilles, Kauffenstein, Cristina Ribas, Fürstenau, Pedro, D'Orléans-Juste, Jean, Sévigny   +3 more
openaire   +2 more sources

Efficient Gene Expression System in Medaka Embryos Enables Functional Characterization of nt5c1a Paralogs Involved in Inosine Monophosphate Metabolism

genesis, Volume 64, Issue 3, June 2026.
ABSTRACT Optimizing transient expression systems in fish embryos is crucial for rapid gene function analysis. Here, we established an efficient system in medaka (Oryzias latipes) embryos by evaluating nucleic acid type and injection site. Our results revealed that injecting the elongation factor 1αA (ef1αA) promoter‐driven plasmid into the yolk yielded
Yu Murakami, Tomohisa Horibe, Masashi Ando, Toru Kobayashi   +3 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Differential Adenosine Signaling and Effects of Acute Caffeine Exposure on Alternative Stress Coping Styles in Zebrafish (Danio rerio)

Brain and Behavior, Volume 16, Issue 5, May 2026.
Acute caffeine exposure exerts coping style‐ and sex‐dependent effects on anxiety‐like behavior in zebrafish, with reactive individuals, particularly males, showing the greatest sensitivity. The accompanying changes in adenosine receptor and adenosine deaminase expression demonstrate a possible molecular mechanism underlying these behavioral ...
Sydney E. Klucas, Ryan Y. Wong
wiley   +1 more source

ATP as Phosphorus and Nitrogen Source for Nutrient Uptake by Fagus sylvatica and Populus x canescens Roots

Frontiers in Plant Science, 2019
The present study elucidated whether roots of temperate forest trees can take up organic phosphorus in the form of ATP. Detached non-mycorrhizal roots of beech (Fagus sylvatica) and gray poplar (Populus x canescens) were exposed under controlled ...
Ursula Scheerer, Niclas Trube, Florian Netzer, Florian Netzer, Heinz Rennenberg, Cornelia Herschbach, Cornelia Herschbach   +6 more
doaj   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source