Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]
, 2015 Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J. +3 more
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Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. [PDF]
PLoS ONE, 2013 Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV ...
Nabanita Biswas +6 more
doaj +1 more source
Transcriptional and Metabolic Investigation in 5′-Nucleotidase Deficient Cancer Cell Lines
Cells, 2021 Enzymes of nucleoside and nucleotide metabolism regulate important cellular processes with potential impacts on nucleotide-unrelated parameters. We have used a set of CRISPR/Cas9-modified cell models expressing both, one, or none of the 5′-nucleotidases ...
Octavia Cadassou +9 more
doaj +1 more source
Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]
, 2008 Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Wall, Mark J., Dale, Nicholas
core +1 more source
Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts. [PDF]
PLoS ONE, 2013 The use of topical and oral adenosine derivatives in HIV prevention that need to be maintained in tissues and cells at effective levels to prevent transmission prompted us to ask whether estradiol could influence the regulation of catabolic nucleotidase ...
Zheng Shen +7 more
doaj +1 more source
Neurobiology of Disease, 2021 Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR).
Elisabete Augusto +11 more
doaj +1 more source
Molecular regulators of glucose and lipid metabolism in skeletal muscle [PDF]
, 2012 Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis.
Kulkarni, Sameer S
core +1 more source
Some aspects of purinergic signaling in the ventricular system of porcine brain
Acta Veterinaria Scandinavica, 2011 Background Numerous signaling pathways function in the brain ventricular system, including the most important - GABAergic, glutaminergic and dopaminergic signaling. Purinergic signalization system - comprising nucleotide receptors, nucleotidases, ATP and
Komoszyński Michał +4 more
doaj +1 more source
PLoS ONE, 2019 5'-nucleotidases are widespread among all domains of life. The enzymes hydrolyze phosphate residues from nucleotides and nucleotide derivatives. In some pathobiontic bacteria, 5'-nucleotidases contribute to immune evasion by dephosphorylating adenosine ...
Marcel-Lino Dangel +6 more
doaj +1 more source
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway [PDF]
, 2015 G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their cellular distribution and ...
Duarte, Thiago +2 more
core +2 more sources