Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide distributions. [PDF]
PLoS Computational Biology, 2020 Nucleotides comprise small molecules that perform critical signaling roles in biological systems. Adenosine-based nucleotides, including adenosine tri-, di-, and mono-phosphate, are controlled through their rapid degradation by diphosphohydrolases and ...
Hadi Rahmaninejad +4 more
doaj +2 more sources
Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. [PDF]
PLoS ONE, 2013 Tenofovir (TFV) has been widely used for pre-exposure prophylaxis of HIV-1 infection with mixed results. While the use of TFV in uninfected individuals for prevention of HIV-1 acquisition is actively being investigated, the possible consequences of TFV ...
Nabanita Biswas +6 more
doaj +3 more sources
Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases [PDF]
Frontiers in Immunology, 2018 Ecto-nucleotidase activity is involved in the infection process of Leishmania and various other parasites that enables modulation of host immune responses to promote disease progression.
Nalu Teixeira de Aguiar Peres +10 more
doaj +2 more sources
Microbial 5′-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications [PDF]
Applied Microbiology and Biotechnology, 2021 Natalia P Zakataeva
exaly +2 more sources
Ecto-nucleotidases Activities in the Contents of Ovarian Endometriomas: Potential Biomarkers of Endometriosis [PDF]
Mediators of Inflammation, 2014 Endometriosis, defined as the growth of endometrial tissue outside the uterus, is a common gynecologic condition affecting millions of women worldwide. It is an inflammatory, estrogen-dependent complex disorder, with broad symptomatic variability, pelvic
Laura Texidó +9 more
doaj +2 more sources
Editorial: Adenosine metabolism in cardiovascular and smooth muscle [PDF]
Frontiers in PharmacologyBarbara Kutryb-Zając +4 more
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Evidence for a Cross-Talk Between Cytosolic 5′-Nucleotidases and AMP-Activated Protein Kinase
Frontiers in Pharmacology, 2020 Marcella Camici +2 more
exaly +3 more sources
Life, 2021 (1) Background: Acupuncture (AP) is a safe and effective analgesic therapy. Understanding how fine needles trigger biological signals can help us optimize needling manipulation to improve its efficiency.
Yawen Zheng +7 more
doaj +1 more source
Spatial mapping of ectonucleotidase gene expression in the murine urinary bladder
Frontiers in Physiology, 2023 Purinergic signaling is important for normal bladder function, as it is thought to initiate the voiding reflex and modulate smooth muscle tone. The availability of adenine nucleotides and nucleosides (aka purines) at receptor sites of various cell types ...
Mafalda S. L. Aresta Branco +2 more
doaj +1 more source
High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors [PDF]
Mediators of Inflammation, 2014 One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
Elisabet Aliagas +5 more
doaj +2 more sources