Results 341 to 350 of about 2,548,202 (389)
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Current Opinion in Neurobiology, 1997
Adenosine 5'-triphosphate (ATP) and/or related nucleotides act at both ionotropic (P2X) and metabotropic (P2Y) receptors. P2X receptor subunits (P2X1-P2X7) form ligand-gated cation channels, as homomultimers or heteromultimers. Recent work indicates that P2X3 subunits participate in channels expressed by nociceptive sensory neurons, and that the second
Barnard, EA, North, RA
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Adenosine 5'-triphosphate (ATP) and/or related nucleotides act at both ionotropic (P2X) and metabotropic (P2Y) receptors. P2X receptor subunits (P2X1-P2X7) form ligand-gated cation channels, as homomultimers or heteromultimers. Recent work indicates that P2X3 subunits participate in channels expressed by nociceptive sensory neurons, and that the second
Barnard, EA, North, RA
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Nature, 1976
It is show that in aqueous solution the backbone conformation of adenosine is as much flexible as that of 3'-AMP, 5'-AMP and 3', 5'-ADP indicating that nucleotides are not any more rigid than nucleosides. The flexible conformation of the monomeric components is conserved in the nucleotidyl units of destacked ApA, ApApA and poly(A), but it is not ...
F E, Evans, R H, Sarma
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It is show that in aqueous solution the backbone conformation of adenosine is as much flexible as that of 3'-AMP, 5'-AMP and 3', 5'-ADP indicating that nucleotides are not any more rigid than nucleosides. The flexible conformation of the monomeric components is conserved in the nucleotidyl units of destacked ApA, ApApA and poly(A), but it is not ...
F E, Evans, R H, Sarma
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Phytochemistry, 2004
The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger ...
Russell P, Newton, Christopher J, Smith
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The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger ...
Russell P, Newton, Christopher J, Smith
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2011
Publisher Summary This chapter discusses the synthesis and degradation of nucleotides. A nucleotide consists of a purine or pyrimidine base, a pentose, and a phosphate. Nucleotides are synthesized by two types of metabolic pathways: de novo synthesis and salvage pathways.
Chung-Eun Ha, N.V. Bhagavan
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Publisher Summary This chapter discusses the synthesis and degradation of nucleotides. A nucleotide consists of a purine or pyrimidine base, a pentose, and a phosphate. Nucleotides are synthesized by two types of metabolic pathways: de novo synthesis and salvage pathways.
Chung-Eun Ha, N.V. Bhagavan
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The Biosynthesis of Nucleotides
2004The synthesis of PRPP from ATP and ribose-5-phosphate is catalyzed by phosphoribosylpyrophosphate synthetase as follows:
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1986
A supply of ribonucleoside and deoxyribonucleoside 5′-triphosphates is required for the biosynthesis of nucleic acids (chapters 6 and 8). The synthesis of these compounds occurs in two main stages: (1) the formation of the purine and pyrimidine ring systems and their conversion into the parent ribonucleoside monophosphate, inosine 5′-monophosphate (IMP)
Roger L. P. Adams +2 more
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A supply of ribonucleoside and deoxyribonucleoside 5′-triphosphates is required for the biosynthesis of nucleic acids (chapters 6 and 8). The synthesis of these compounds occurs in two main stages: (1) the formation of the purine and pyrimidine ring systems and their conversion into the parent ribonucleoside monophosphate, inosine 5′-monophosphate (IMP)
Roger L. P. Adams +2 more
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Biochemistry, 1984
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration.
H. Hidaka +3 more
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Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration.
H. Hidaka +3 more
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The separation of nucleotides by isotachophoresis
Journal of Chromatography A, 1972The mono-, di-, and triphosphates of adenosine, cytidine, guanosine, and uridine were sepd. by isotachophoresis in several different electrolyte systems. At lower pH, the differences in step-height were greater, and complete sepn. of a mixt.
FM Frans Everaerts, JL Jozef Beckers
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Science, 1998
Single-nucleotide polymorphisms (SNPs) are the most frequent type of variation in the human genome, and they provide powerful tools for a variety of medical genetic studies.
David G. Wang +26 more
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Single-nucleotide polymorphisms (SNPs) are the most frequent type of variation in the human genome, and they provide powerful tools for a variety of medical genetic studies.
David G. Wang +26 more
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Fluorinated Nucleosides, Nucleotides and Sugar Nucleotides
Future Medicinal Chemistry, 2023Jonathan P Dolan +3 more
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