Results 111 to 120 of about 126,964 (313)

Spatial and temporal cellular responses to single-strand breaks in human cells [PDF]

, 2003
DNA single-strand breaks (SSB) are one of the most frequent DNA lesions produced by reactive oxygen species and during DNA metabolism, but the analysis of cellular responses to SSB remains difficult due to the lack of an experimental method to produce ...
Caldecott, Keith W, Lan, Li, Mori, Toshio, Okano, Satoshi, Yasui, Akira   +4 more
core   +4 more sources

Comparative analysis of the nucleotide composition biases in exons and introns of human genes [PDF]

arXiv, 2010
The nucleotide composition of human genes with a special emphasis on transcription-related strand asymmetries is analyzed. Such asymmetries may be associated with different mutational rates in two principal factors. The first one is transcription-coupled repair and the second one is the selective pressure related to optimization of the translation ...
arxiv  

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data [PDF]

, 2013
<p>Purpose: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of ...
A Choudhury, A Torkamani, AL Dixon, AP Bazo, B Arcidiacono, Bastiaan T. Heijmans, BJ Lamarche, Brendan M. Buckley, C Matthews, CD Ragnauth, Consortium Wellcome Trust Case Control, D Thorne, David J. Stott, E Durand, E Poch, F Gizard, G Bauriedel, G Macintyre, G Perez-Rivero, G Voghel, GJ Williams, GS Stewart, H Gui, H Schunkert, Henk-Jan Guchelaar, HY Shyu, Ian Ford, IS Ockene, J Shepherd, J Shepherd, J. Wouter Jukema, Jeanine J. Houwing-Duistermaat, Jeffrey J. W. Verschuren, Joris Deelen, JR Mercer, K Allen-Brady, K Wang, LS Waters, M Corral-Debrinski, M Durik, M Kanehisa, M Mahmoudi, M Satoh, MA Loizidou, MF Moffatt, MG Andreassi, MK Shimada, ML Rossi, ML Sampietro, Naveed Sattar, NJ Samani, OK Mirzoeva, P. Eline Slagboom, S Furukawa, S Knudsen, S Mahabir, S Ozturk, S Purcell, S Purcell, S Trompet, SC Liu, Sergey Korolev, Stella Trompet, T Minamino, T Zeller, V Borde, V Borde, WR Agema, X Xie, Y Li, YB Park   +70 more
core   +3 more sources

Relationships among the nucleotide content of human genome sequence, gene structure, and gene expression features (PhD synopsis) [PDF]

arXiv, 2010
The Dissertation is focused on the studies of associations between functional elements in human genome and their nucleotide structure. The asymmetry in nucleotide content (skew, bias) was chosen as the main feature for nucleotide structure. A significant difference in nucleotide content asymmetry was found for human exons vs. introns.
arxiv  

Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis*

Journal of Biological Chemistry, 2014
Background: XPC protein is ubiquitinated, but the ubiquitination does not lead to significant proteolysis of XPC. Results: Ubiquitin-specific protease 7 is a deubiquitinating enzyme (DUB) for XPC.
Jinshan He, Qianzheng Zhu, G. Wani, Nidhi Sharma, Chunhua Han, J. Qian, Kyle Pentz, Qi-En Wang, A. Wani   +8 more
semanticscholar   +1 more source

Biochemical characterization and DNA repair pathway interactions of Mag1-mediated base excision repair in Schizosaccharomyces pombe [PDF]

, 2005
The Schizosaccharomyces pombe mag1 gene encodes a DNA repair enzyme with sequence similarity to the AlkA family of DNA glycosylases, which are essential for the removal of cytotoxic alkylation products, the premutagenic deamination product hypoxanthine ...
Alseth, I, Bjoras, M, Korvald, H, Osman, F, Seeberg, E, Tsaneva, I, Whitby, MC   +6 more
core   +5 more sources

DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

Cell Reports, 2020
Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée, Gytis Jankevicius, Charles Cooper, Ivan Ahel, Stephan Uphoff, Christoph M. Tang   +5 more
doaj  

Chromatin structure and DNA damage repair

Epigenetics & Chromatin, 2008
The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks, single strand breaks, oxidative lesions and ...
Dinant Christoffel, Houtsmuller Adriaan B, Vermeulen Wim   +2 more
doaj   +1 more source

Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair

Cells, 2020
LAP2-Emerin-MAN1 (LEM) domain-containing proteins represent an abundant group of inner nuclear membrane proteins involved in diverse nuclear functions, but their functional redundancies remain unclear.
Bernhard Moser, José Basílio, Josef Gotzmann, Andreas Brachner, Roland Foisner   +4 more
doaj   +1 more source

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

Nucleic Acids Research, 2014
The proliferating cell nuclear antigen (PCNA) protein serves as a molecular platform recruiting and coordinating the activity of factors involved in multiple deoxyribonucleic acid (DNA) transactions. To avoid dangerous genome instability, it is necessary
O. Cazzalini, S. Sommatis, M. Tillhon, Ilaria Dutto, A. Bachi, A. Rapp, T. Nardò, A. Scovassi, D. Necchi, M., Cristina Cardoso, L. Stivala, E. Prosperi   +12 more
semanticscholar   +1 more source